Simple Renal Cysts in Hypertensive Patients: Relation between Cyst Growing and Anti-Hypertensive Therapy

Schiavone, Cosima; Salvatore, Lisa; Primavera, Alessandra; Cuccurullo, Franco; Verna, N; Stefano, Francesca Di; Thomson, Emma C.; Tenaglia, R.; Gioacchino, Mario Di

doi:10.1177/039463200301600212

Cited by 3 publications

(2 citation statements)

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“…During ageing, both in humans and in laboratory animals, many alterations of renal functions have been reported (25,26). Renal ageing is associated with a progressive decline of glomerular filtration and of renal blood flow along with vascular resistance (27)(28)(29)(30)(31)(32). In this study, we observed in the rat kidney, an increase of the expression of iNOS during ageing .…”

Section: S Inos Old Rat Kidneysupporting

confidence: 51%

A Scavenger Role for Nitric Oxide in the Aged Rat Kidney

Lutiis¹,

Felaco²,

Gizzi³

et al. 2004

Int J Immunopathol Pharmacol

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Progressive ageing is associated with an increment of biomolecules modified through oxidation as a result of the action of free radicals deriving from reactive oxygen species that attack biomolecules. During ageing many alterations of renal functions have been reported. Renal ageing is associated with a progressive decline of glomerular filtration, renal blood flow and augmented vascular resistance. The kidney is a very important source of inducible nitric oxide synthase (iNOS) in both epithelial and vascular structures. In this study we have investigated mRNA and protein iNOS expression and localization and nitric oxide (NO) production in young and aged rats. An increased expression of iNOS occurs in rat kidney during ageing. In the aged rat, an increase in the values of both iNOS-RNA and iNOS protein was observed through rtPCR and Western blot analysis. The activities of three isoforms of NOS were also seen. In the aged rat kidney the production of NO decreased, due to the reduction of the activities of the three NOS. This suggests that in the aged rat a progressive increase of superoxide anion does not imply an increase in the production of NO which functions as a scavenger molecule, causing oxidative stress with accumulation of reactive oxygen species (ROS).

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Section: S Inos Old Rat Kidneysupporting

confidence: 51%

A Scavenger Role for Nitric Oxide in the Aged Rat Kidney

Lutiis¹,

Felaco²,

Gizzi³

et al. 2004

Int J Immunopathol Pharmacol

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“…Consistently, decreased calcium concentration has been documented in AD patients [ 25 ], which could be attributed to calcium loss resulting from the administration of diuretics for blood pressure control [ 26 ]. Interestingly, clinical studies demonstrated that

-antagonists were related to the enlargement of simple renal cysts [ 27 ]. Clinically, calcification-induced degradation presents a reduction in stiffness of the aortic wall [ 23 ].…”

Section: Commentmentioning

confidence: 99%

Long-Term Outcomes of Endovascular Treatment for Type B Aortic Dissection with Simple Renal Cysts: A Multicenter Retrospective Study

Zhu¹,

Zhao²,

Wang³

et al. 2022

Rev. Cardiovasc. Med.

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Background: Few studies have investigated the characteristics and long-term outcomes of type B aortic dissection (BAD) patients with simple renal cysts (SRC) after thoracic endovascular aortic repair (TEVAR). Methods: A multi-center retrospective cohort study was performed, including 718 BAD patients undergoing TEVAR from 2003 to 2016. The prevalence of SRC was 34.5% (n = 248). After propensity score matching, 214 matched pairs were selected for further analysis. Primary outcomes were long-term aortic-related adverse events (ARAEs). The effects of SRC in each subgroup of interest and their interactions were analyzed. Results: BAD patients with SRC were older and had a greater prevalence of comorbidities, including hypertension, coronary artery disease and chronic occlusive pulmonary disease. In addition, the SRC group presented a greater proportion of pleural effusion and aortic calcification. Compared with the non-SRC group, a significantly higher maximal diameter of ascending aorta was observed in the SRC group. Apart from the timing of the operation, no differences were found in the medication regime or intra-operative parameters. In the matched population, patients with SRC were at a higher risk of ARAEs in the long term. The multivariable Cox model indicated that SRC was an independent predictor of long-term ARAEs (hazard ratio: 1.84, 95% confidence interval: 1.13-3.00). The interaction between SRC and hypertension on rupture after TEVAR was statistically significant (p = 0.023). Conclusions: Compared with the non-SRC group, BAD patients with SRC experienced a higher risk of long-term ARAEs after TEVAR. Among the SRC subgroup, hypertensive patients had the highest risk of rupture after TEVAR.

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