Simple renal cysts in the solitary kidney: Are they innocent in adult patients?

Tatar, Erhan; Özay, Emine; Atakaya, Mehmet; Yeniay, Pinar Kezban; Aykaş, Ahmet; Okut, Gökalp; Yonguç, Tarık; İmamoğlu, Çetin; Uslu, Adam

doi:10.1111/nep.12778

Cited by 10 publications

(9 citation statements)

References 22 publications

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“…The conclusion was that the relative renal function of the cystic kidney was lower than that of the contralateral kidney (p = 0.001). Another recent study further verified whether cysts with moderate renal dysfunction were associated with poor renal result in patients with a solitary kidney [19] . On the contrary, Rule et al [8] found renal cysts to be associated with increased GFR (hyperfiltration) in the potential donor population.…”

Section: Discussionmentioning

confidence: 99%

Simple Cysts in Donor Kidney Contribute to Reduced Allograft Function

Qiu

Jiang²,

Wu³

et al. 2016

Am J Nephrol

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Background: Simple renal cysts may be an early marker of renal disease. We investigated whether simple cysts in donor kidney are associated with the decline of allograft function in living donor kidney transplantation. Methods: We retrospectively reviewed records of donors and recipients from 716 living donor kidney transplants performed between April 2007 and April 2015 in our hospital. Ninety-one donors with renal cysts and 64 recipients with cysts in donor kidney were noted. We compared these 64 cases to 128 no cyst-bearing controls matched for the donor gender, recipient gender, donor baseline serum creatinine (sCr), donor/recipient body surface area ratio, donor age, recipient age and the date of kidney transplantation in turn. Results: The presence of cysts was interrelated with age, gender and renal function independently in donors. Pathological findings of time-zero biopsy revealed that donor kidney harboring cysts existed more glomerular sclerosis compared with no cyst-bearing controls (p = 0.040). The estimating glomerular filtration rate levels of recipients were 80.82 ± 26.61 vs. 88.21 ± 23.12, 66.95 ± 17.42 vs. 72.15 ± 16.42 and 60.92 ± 22.17 vs. 68.72 ± 14.43 ml/min· 1.73 m² in cyst-bearing and no cyst-bearing group on day 7, month 6 and year 5, respectively, after surgery (p < 0.05). The mean sCr were 112.14 ± 48.32 vs. 98.75 ± 29.71 and 126.28 ± 42.32 vs. 115.05 ± 26.35 μmol/l on the 7th day and a half year after transplant, respectively (p < 0.05). The 2 groups did not significantly differ in terms of the other characteristics. Conclusion: Simple cysts in donor kidney can influence the early and long-term allograft function. In living donor transplantation, kidney presenting cysts should be considered carefully at the time of donor selection.

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Section: Discussionmentioning

confidence: 99%

Simple Cysts in Donor Kidney Contribute to Reduced Allograft Function

Qiu

Jiang²,

Wu³

et al. 2016

Am J Nephrol

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“…Tatar et al. 23 reported that SRCs are associated with poor renal function outcomes in solitary kidney patients. In Korea, Choi et al.…”

Section: Discussionmentioning

confidence: 99%

Development and external validation of a nomogram for predicting renal function based on preoperative data from in-hospital patients with simple renal cysts

Chen

Meng

et al. 2022

J Int Med Res

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Objective To develop and validate a nomogram for predicting renal dysfunction in patients with simple renal cysts (SRCs). Methods We performed a multivariable logistic regression analysis of an in-hospital retrospective cohort of patients with SRCs in the Urology Department of the First Affiliated Hospital of Anhui Medical University. For prognostic model development, 386 patients with SRCs were enrolled from January 2016 to December 2018. External validation was performed in 46 patients with SRCs from January 2019 to April 2019. The primary outcome was renal dysfunction. Results Patients were divided into normal or abnormal estimated glomerular filtration rate groups (293 vs. 93) based on the cut-off value of 90 mL/minute/1.73 m2. Logistical regression analysis determined that age, haemoglobin, globulin, and creatinine might be associated with renal dysfunction, and a novel nomogram was established. Calibration curves showed that the true prediction rate was 77.42%, and decision curve analysis revealed that the nomogram was more effective with threshold probabilities ranging from 0.1 to 0.8. The area under the curves were 0.829, 0.752, and 0.888 in the overall training, internal, and external validation cohorts, respectively. Conclusions We established a nomogram to predict the probability of developing renal dysfunction in patients with SRCs.

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“…The association of membranoproliferative glomerulonephritis (MPGN) with solid tumour remains rare. [1][2][3][4][5][6][7] MPGN is more typical of lymphoproliferative disorders. 8 A 65-year-old gentleman, hypertensive for 5 years, presented with a history of pedal oedema, facial puffiness and breathlessness for 20 days duration.…”

Section: Venkateswara Institute Of Medical Sciences Nephrologymentioning

confidence: 99%

“…We read the interesting paper recently published by Tatar et al in Nephrology . In a cohort of 65 adult patients who underwent nephrectomy for oncological and non‐oncological causes, simple renal cyst was present in 30% of patients.…”

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confidence: 99%