Simple segmental hair analysis for α-pyrrolidinophenone-type designer drugs by MonoSpin extraction for evaluation of abuse history

New Challenges and Perspectives in Hair Analysis

“…The timeline of cocaine disappearance from growing hair was investigated within the implementation of rehabilitation programs involving drug abstinence. More precise correlation between consumption pattern and head hair concentration was found for methamphetamine [82], and the first reports that connect segmental hair analysis to the consumption history of cathinone-and pyrrolidinophenone-type new designer drugs in real cases of chronic intoxication have already been published [83,84]. The absolute and relative hair concentrations of THC and 11-nor-9-carboxy-Δ 9 -tetrahydrocannabinol (THC-COOH) were studied in both self-reporting and controlled administration of cannabis products, revealing limited dependence on consumption frequency [80], scattered absolute concentration values, and generalized decrease of THC-COOH from proximal to distal segments [81].…”

Detection of New Psychoactive Substances

“…The method was applied to the analysis of seven hair specimens positive to amphetamine derivatives. Namera et al [42] described a simple quantitative method for identifying cathinone analogues in 10-mm-long hair segments. Unfortunately, no information was available to elucidate if this subject was under prescription of trazodone.…”

“…New compounds made with small structural modifications such as α-pyrrolidinovalerophenone (α-PVP) and α-pyrrolidinopentiothiophenone (α-PVT) continue to appear on the market [42]. New compounds made with small structural modifications such as α-pyrrolidinovalerophenone (α-PVP) and α-pyrrolidinopentiothiophenone (α-PVT) continue to appear on the market [42].…”

Recent Advances and Uses of Monolithic Columns for the Analysis of Residues and Contaminants in Food

“…This simple method requires a low elution volume and does not require solvent evaporation. The spin-column technique has been used to extract various analytes in different matrices, mainly for toxicological analysis of human specimens (urine and serum) [65][66][67]. Very few examples of the application of these devices in the analysis of food can be found in the literature of the last five years, basically due to the complex characteristics of edible matrices.…”