This study aims to carry out a seismic risk assessment for a typical mid-size city based on building inventory from a field study. Contributions were made to existing loss estimation methods for buildings. In particular, a procedure was introduced to estimate the seismic quality of buildings using a scoring scheme for the effective parameters in seismic behavior. Denizli, a typical mid-size city in Turkey, was used as a case study. The building inventory was conducted by trained observers in a selected region of Denizli that had the potential to be damaged from expected future earthquakes according to geological and geotechnical studies. Parameters that are known to have some effect on the seismic performance of the buildings during past earthquakes were collected during the inventory studies. The inventory includes data of about 3,466 buildings on 4,226 parcels. The evaluation of inventory data provided information about the distribution of building stock according to structural system, construction year, and vertical and plan irregularities. The inventory data and the proposed procedure were used to assess the building damage, and to determine casualty and shelter needs during the M6.3 and 7.0 scenario earthquakes, representing the most probable and maximum earthquakes in Denizli, respectively. The damage assessment and loss studies showed that significant casualties and economic losses can be expected in future earthquakes. Seismic risk assessment of reinforced concrete buildings also revealed the priorities among building groups. The vulnerability in decreasing order is: (1) buildings with 6 or more stories, (2) pre-1975 constructed buildings, and (3) buildings with 3-5 stories. The future studies for evaluating and reducing M. Inel (&) Á S. M. Senel Á S. Toprak Á Y. Manav