Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Abstract

Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.

Hydroperoxyditerpenoids from Octocorals

“…[15] Eunicellin 20 showed activity against the proliferation of K-562, CCRF-CEM, T-47D, and MOLT-4 tumor cells, with ED 50 values of 15.9, 5.9, 29.7, and 8.4 μM, respectively. [16]…”

“…Three hydroperoxyeunicellins, klysimplexins D (18) and M (19), along with simplexin R (20) (Figure 10), were isolated from K. simplex. [14][15][16] The structures of eunicellins 18-20 were determined by spectroscopic methods. At a concentration of 10 μM, eunicellin 19 was found to significantly reduce the expression of inducible nitrogen oxide synthase (iNOS).…”

Cytotoxic and Anti-Inflammatory Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

“…Previous studies showed that many eunicellin-based diterpenes discovered from soft corals exhibited cytotoxic and anti-inflammatory activities [1,2,3,4,5,6,7,8,9,10,11,12,13,14]. The soft coral Cladiella krempfi has been found to generate several types of metabolites including eunicellin-type diterpenoids [15] and pregnane-type steroids [16,17,18].…”

Krempfielins J-M, New Eunicellin-Based Diterpenoids from the Soft Coral Cladiella krempfi

“…Many recent studies about the discovery of versatile structures and bioactivities of eunicellin-type compounds isolated from soft corals have been reported [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15]. The soft coral Cladiella krempfi has been found to generate several types of metabolites including eunicellin-type diterpenoids [16,17] and pregnane-type steroids [18,19,20].…”