2019
DOI: 10.1159/000496396
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Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusions

Abstract: Background: An important part of the investigation of pleural effusion is the identification of markers that help separate exudate from transudate. Objectives: The purposes of this study were to compare the accuracy of published and new sets of criteria to distinguish between exudative and transudative pleural effusions, and to determine whether serum biochemical analysis is necessary. Methods: An externally validated cohort study was performed. Pleural effusions were determined to be transudative or exudative… Show more

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Cited by 13 publications
(7 citation statements)
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“…A final hypothetical mechanism linking the lipid profile and COVID-19 concerns the altered vascular permeability induced by SARS-COV-2 infection, which can lead to the accumulation of exudative fluids in the alveoli [ 5 , 6 ]. As effusion contains proteins and cholesterol [ 18 , 19 , 20 ], the cholesterol exudate accumulating in the alveolar cavities due to the increase in vascular permeability could lead to a reduction in serum cholesterol levels.…”
Section: Discussionmentioning
confidence: 99%
“…A final hypothetical mechanism linking the lipid profile and COVID-19 concerns the altered vascular permeability induced by SARS-COV-2 infection, which can lead to the accumulation of exudative fluids in the alveoli [ 5 , 6 ]. As effusion contains proteins and cholesterol [ 18 , 19 , 20 ], the cholesterol exudate accumulating in the alveolar cavities due to the increase in vascular permeability could lead to a reduction in serum cholesterol levels.…”
Section: Discussionmentioning
confidence: 99%
“…The study was approved by the Ethics Committee of the Hospital. MPE 21,23 : find malignant cells in PE and/or on closed pleural biopsy specimen. (In our study, all the MPEs are secondary to metastases to the pleura from lung).…”
Section: Study Subjectsmentioning
confidence: 99%
“…On the other hand, the differential leukocyte count is of interest in all pleural exudates because the predominance of a specific cell type, either neutrophils or lymphocytes, can help to narrow down the differential diagnosis. identification of exudates (94% sensitivity and 88% specificity) [21][22][23] .…”
Section: Leukocyte Cell Countmentioning
confidence: 99%