Simplified miniaturized ultrasound-assisted matrix solid phase dispersion extraction and high performance liquid chromatographic determination of seven flavonoids in citrus fruit juice and human fluid samples: Hesperetin and naringenin as biomarkers

Barfi, Behruz; Asghari, Alireza; Rajabi, Maryam; Barfi, Azadeh; Saeidi, Iman

doi:10.1016/j.chroma.2013.08.078

Cited by 74 publications

(24 citation statements)

References 43 publications

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“…In a miniaturized UA-MSPD method to extract seven flavonoids from citrus fruit juice, and human urine and plasma samples, Barfi et al [9] loaded a 150-µL sample directly into a 1-mL syringe barrel fitted with a PTFE frit and containing 200 mg of C18. Then, both ends of the syringe were closed with polypropylene caps and the syringe was immersed in ultrasonic water bath for 6 min at room temperature to disperse the sample.…”

Section: Ultrasound-assisted Mspd (Ua-mspd)mentioning

confidence: 99%

“…The choices of solid support and elution solvent determine the efficiency and the selectivity of the process. Generally, MSPD requires a low consumption of organic solvents, especially if miniaturized [9]. Although extraction based on this technique is quite rapid, it cannot be fully automated, and this represents an obstacle when routine analyses have to be performed on large sample sets.…”

Section: Introductionmentioning

confidence: 99%

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Recent advances and developments in matrix solid-phase dispersion

Capriotti

Cavaliere

Foglia

et al. 2015

TrAC Trends in Analytical Chemistry

107

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Section: Ultrasound-assisted Mspd (Ua-mspd)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent advances and developments in matrix solid-phase dispersion

Capriotti

Cavaliere

Foglia

et al. 2015

TrAC Trends in Analytical Chemistry

107

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“…Flavonoids are natural polyphenols that widely exist in plant tissues. Research shows that the flavonoids have many excellent biological activities such as antioxidant, anticarcinogenic, anti‐inflammatory, and anti‐aging effects . In our daily life, the flavonoid compounds are mainly used in the production and development of healthcare products and clinical drugs that are consumed by people in a large quantity .…”

Section: Introductionmentioning

confidence: 99%

Zinc sulfide nanosheets as a novel solid-phase extraction material for flavonoids

Wang

et al. 2017

J. Sep. Sci.

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As a novel solid-phase extraction material, zinc sulfide nanosheets were prepared by a simple method and were used to extract flavonoids. We used scanning electron microscopy to show its nanosheet morphology and energy dispersive X-ray spectroscopy and powder X-ray diffraction to confirm its chemical and phase compositions. Coupled to a high-performance liquid chromatography, the zinc sulfide nanosheets were packed into a microcolumn and were used to extract four model flavonoids to examine their extraction ability. The parameters of sample loading and elution were investigated. Under optimized conditions, the analytical method for flavonoids was established. For the method, wide linearities from 1 to 250 μg/L and low limits of detection from 0.25 to 0.5 μg/L were obtained. The relative standard deviations for single column repeatability and column to column reproducibility were less than 7.7 and 10.4%, respectively. The established method was also used to analyze two real samples and the recoveries from 88.7 to 98.2% further proved the reliability of the method. Moreover, the zinc sulfide nanosheets have good stability and that in one column can be reused for more than 50 times. This work proves that the prepared zinc sulfide nanosheets are a good candidate as the flavonoids sorbent.

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“…Among these methods, matrix solid‐phase dispersion (MSPD), based the dispersion of a sample on a selective solid phase, has been found to be a novel sample preparation technique with increasing acceptance . This method has been applied to the preparation, extraction, and fractionation of a large number of substances from solid, semisolid, and highly viscous biological samples, such as drug, food, plant, soil, plasma, and animal tissues . Low consumption of sample and solvents, straightforward application, simplicity and the capability to simultaneously perform extraction and clean up in a single process are among its major advantages .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and application of mesoporous molecular sieve for miniaturized matrix solid‐phase dispersion extraction of bioactive flavonoids from toothpaste, plant, and saliva

Cao

et al. 2015

Electrophoresis

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This article describes the use of the mesoporous molecular sieve KIT-6 as a sorbent in miniaturized matrix solid-phase dispersion (MSPD) in combination with ultra-performance LC for the determination of bioactive flavonoids in toothpaste, Scutellariae Radix, and saliva. In this study, for the first time, KIT-6 was used as a sorbent material for this mode of extraction. Compared with common silica-based sorbents (C18 and activated silica gel), the proposed KIT-6 dispersant with a three-dimensional cubic Ia3d structure and highly ordered arrays of mesoporous channels exhibits excellent adsorption capability of the tested compounds. In addition, several experimental variables, such as the mass ratio of sample to dispersant, grinding time, and elution solvent, were optimized to maximize the extraction efficiency. The proposed analytical method is simple, fast, and entails low consumption of samples, dispersants and elution solvents, thereby meeting "green chemistry" requirements. Under the optimized conditions, the recoveries of three bioactive flavonoids obtained by analyzing the spiked samples were from 89.22 to 101.17%. Also, the LODs and LOQs for determining the analytes were in the range of 0.02-0.04 μg/mL and 0.07-0.13 μg/mL, respectively. Finally, the miniaturized matrix solid-phase dispersion method was successfully applied to the analysis of target solutes in real samples, and satisfactory results were obtained.

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Simplified miniaturized ultrasound-assisted matrix solid phase dispersion extraction and high performance liquid chromatographic determination of seven flavonoids in citrus fruit juice and human fluid samples: Hesperetin and naringenin as biomarkers

Cited by 74 publications

References 43 publications

Recent advances and developments in matrix solid-phase dispersion

Recent advances and developments in matrix solid-phase dispersion

Zinc sulfide nanosheets as a novel solid-phase extraction material for flavonoids

Synthesis and application of mesoporous molecular sieve for miniaturized matrix solid‐phase dispersion extraction of bioactive flavonoids from toothpaste, plant, and saliva

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