Simply and sensitively simultaneous detection hepatocellular carcinoma markers AFP and miRNA-122 by a label-free resonance light scattering sensor

Chen, Feng; Zhang, Feng; Liu, Yi; Cai, Changqun

doi:10.1016/j.talanta.2018.04.060

Cited by 43 publications

(16 citation statements)

References 33 publications

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“…Therefore, dynamic monitoring of the CEA concentration is highly significant in the diagnosis and treatment of liver cancer. Detection of multiple tumor markers (see ESI †) can provide improved accuracy of diagnosis, 15 thereby allowing cancer patients to receive real-time treatment and increase their survival rate. Therefore, it is of great significance to exploit a joint detection technology with high sensitivity and excellent selectivity for liver cancer biomarkers.…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

Liu

Wang

et al. 2022

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

Liu

Wang

et al. 2022

Biomater. Sci.

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“…124 Circulating MiR-122 is a sensitive biomarker of liver injury. 125,126 MiR-122 level was significantly decreased in HCC patients, while patients with higher miR-122 level had a lower postoperative recurrence rate. Codelivery of miR-122 and 5-fluorouracil (5-FU) using a macromolecular prodrug approach was a highly promising strategy toward HCC synergistic therapy.…”

Section: Mirna S In the Prog Nos Ti C A Ss E Ss Ment Of H Ccmentioning

confidence: 89%

“…MiR‐122 is a completely conserved liver‐specific miRNA in vertebrates, which is essential for maintaining liver homeostasis 124 . Circulating MiR‐122 is a sensitive biomarker of liver injury 125,126 . MiR‐122 level was significantly decreased in HCC patients, while patients with higher miR‐122 level had a lower postoperative recurrence rate.…”

Section: Mirnas In the Prognostic Assessment Of Hccmentioning

confidence: 99%

Involvement of microRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma

Zhou

Liu

et al. 2022

Clinical Laboratory Analysis

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In the treatment of hepatocellular carcinoma (HCC), although surgical resection, interventional therapy, radiotherapy/chemotherapy, targeted therapy, immunotherapy, and liver transplantation are effective, the 5-year survival rate is still meager. The main reason is that HCC is more prone to recurrence and metastasis.Furthermore, HCC has an insidious onset and progresses slowly, and patients often miss the optimal time for treatment. 1 MicroRNAs (miRNAs) are non-coding single-stranded RNAs first discovered in Caenorhabditis. elegans in 1993. They are highly conserved and widely exist in animals, plants, and some viruses. 2 miRNAs promote the degradation of target genes or inhibit the translation of target genes through complementary base pairing, thus achieving the post-transcriptional regulation of target genes. 3 The pathological processes of many diseases, including cancer, metabolic diseases,

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“…Up to now, there have been many reviews on miRNA biosensing [ 37 - 44 ]. Since this area evolves fast, it is necessary to update the existing knowledge.…”

Section: Introductionmentioning

confidence: 99%

A Combinational Approach for More Efficient miRNA Biosensing

Lee

2022

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A microRNAs, short single-stranded noncoding RNAs ranging in length from 18 ~ 24 bp, are found in all kingdoms of eukaryotes and even viruses. It was found that miRNAs got involved in a variety of biological phenomenon control and their intracellular aberrant expression was related to diseases and abnormalities in the immune system. Since then, it has been considered essential to develop an efficient miRNA detection system. In this review, the limitations of traditional scheme-based miRNA detection methods are compared and analyzed. In particular, nucleic acid amplification based miRNA detection methods and nanomaterial-based miRNA detection methods, which are widely used as a biosensing platform because of such features and advantages as high sensitivity, specificity, and simplicity were analyzed. Based on this analysis, the latest examples of combination of advantages of nucleic acid amplification and the features and advantages of nanomaterials are examined to suggest the characteristics of the next generation of miRNA biosensing.

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Simply and sensitively simultaneous detection hepatocellular carcinoma markers AFP and miRNA-122 by a label-free resonance light scattering sensor

Cited by 43 publications

References 33 publications

A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

A highly sensitive silicon nanowire array sensor for joint detection of tumor markers CEA and AFP

Involvement of microRNAs and their potential diagnostic, therapeutic, and prognostic role in hepatocellular carcinoma

A Combinational Approach for More Efficient miRNA Biosensing

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