Simulated post-exposure rabies vaccination with purified chick embryo cell vaccine using a modified Thai Red Cross regimen

Abstract

It can be concluded from the results that an adequate antibody response can be obtained with PCEC vaccine when administered by the TRC regimen even after reducing the quantity of vaccine from 0.2 ml to 0.1 ml per intradermal dose. The feasibility of using this regimen in true post-exposure cases needs to be further evaluated.

Clinical evaluation of purified chick embryo cell rabies vaccine administered intradermally in animal exposures

“…A study conducted by Madhusudana et al, showed that the incidence of ADEs was 9.5% with the use of purified cell culture rabies vaccine (PCECV) and another study by Sudarshan et al, with PCECV using KIMS intradermal regimen also showed a total ADEs of 3.1. 7,8 Therefore, the safety of study vaccines was comparable to other studies and it confirms that available PCECV is safe for PEP among animal bite victims.…”

Evaluation of a new five-injection, two-site,intradermal schedule for purified chick embryo cell rabies vaccine: A randomized, open-label, active-controlled trial in healthy adult volunteers in India

“…However, the cost of 1 dose of IM CCV is $4 to $6, which is not affordable by most people living in India. 17 Although PCECV and PVRV are WHO approved for ID administration, 18 these CCVs have not been approved for ID administration by the DCGI. The ICMR is investigating the feasibility of administering PCECV, PVRV, and PDEV by the ID route following the original TRC regimen ("2-2-2-0-1-1") (unpublished document, ICMR, 2004).…”

Safety and immunogenicity of intradermal rabies vaccination for post exposure prophylaxis

“…Similar results were shown in a study conducted by Madhusudana et al with ADEs of 9.5% with the use of purified cell culture rabies vaccine (PCECV), and study by Sudarshan, et al with PCECV using KIMS regimen also showed a total ADEs of 3.1. 6,7 Similarly, Sampath et al also showed that, the total ADEs of 5.50% for purified vero cell rabies vaccine. 8 Therefore, the safety of study vaccines was comparable to other studies and it confirms that IDRV is safe for PEP among animal bite victims.…”

“…10 Similarly, a study conducted by Madhusudana et al using TRC regimen showed GMC of 4.3IU/mL on day 14. 6 In a study by Sudarshan, et al using KIMS regimen (2-2-2-2-2) also showed GMC of 4.17IU/mL on day 14. 7 The immunogenicity of the intradermal rabies vaccines in the present study were similar to other studies and it confirms the immunogenicity of IDRV among animal bite victims.…”