Simulating convergent extension by way of anisotropic differential adhesion

Zajac, Mark; Jones, Gregory S.; Glazier, James A.

doi:10.1016/s0022-5193(03)00033-x

Cited by 116 publications

(90 citation statements)

References 37 publications

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“…While the cellular behavior and the driving force for radial intercalation is unclear, it is known that during mediolateral intercalation, cells are polarized or elongated along mediolateral axis and project mediolaterally oriented lamellapodia Keller, 1991, Keller, 2002). Computational models suggest that force generated by the protrusive activity of the cells along the mediolateral axis is sufficient to drive the intercalation of cells along the same axis (Zajac et al, 2003, Brodland, 2006, Brodland and Veldhuis, 2006. This hypothesis is consistent with the observation that actin-myosin cytoskeletal components are required for cellular intercalation (Zallen and Wieschaus, 2004).…”

Section: Convergent Extension In the Developing Organ Of Cortisupporting

confidence: 81%

“…Ultimately, the affinity among constituent cells and the affinity between the cells and their extracellular matrix determine the cellular arrangement and consequently the morphology of a particular tissue or organ (Townes and Holtfreter, 1955, Nose et al, 1988, Steinberg and Takeichi, 1994, McNeill, 2000, Zajac et al, 2003. In vitro, differential cellular affinity can drive cellular aggregation and cellular rearrangement (Townes and Holtfreter, 1955, Nose et al, 1988, Steinberg and Takeichi, 1994, McNeill, 2000, Zajac et al, 2003, Strutt et al, 2004, Saburi and McNeill, 2005.…”

Section: Cell Adhesion and Pcp Signaling In The Organ Of Cortimentioning

confidence: 99%

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Shaping the mammalian auditory sensory organ by the planar cell polarity pathway

Kelly

Chen

2007

Int. J. Dev. Biol.

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The human ear is capable of processing sound with a remarkable resolution over a wide range of intensity and frequency. This ability depends largely on the extraordinary feats of the hearing organ, the organ of Corti and its sensory hair cells. The organ of Corti consists of precisely patterned rows of sensory hair cells and supporting cells along the length of the snailshaped cochlear duct. On the apical surface of each hair cell, several rows of actin-containing protrusions, known as stereocilia, form a "V"-shaped staircase. The vertices of all the "V"-shaped stereocilia point away from the center of the cochlea. The uniform orientation of stereocilia in the organ of Corti manifests a distinctive form of polarity known as planar cell polarity (PCP). Functionally, the direction of stereociliary bundle deflection controls the mechanical channels located in the stereocilia for auditory transduction. In addition, hair cells are tonotopically organized along the length of the cochlea. Thus, the uniform orientation of stereociliary bundles along the length of the cochlea is critical for effective mechanotransduction and for frequency selection. Here we summarize the morphological and molecular events that bestow the structural characteristics of the mammalian hearing organ, the growth of the snail-shaped cochlear duct and the establishment of PCP in the organ of Corti. The PCP of the sensory organs in the vestibule of the inner ear will also be described briefly.

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Section: Convergent Extension In the Developing Organ Of Cortisupporting

confidence: 81%

Section: Cell Adhesion and Pcp Signaling In The Organ Of Cortimentioning

confidence: 99%

Shaping the mammalian auditory sensory organ by the planar cell polarity pathway

Kelly

Chen

2007

Int. J. Dev. Biol.

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“…Elongated cells with anisotropic adhesive properties are predicted on the basis of physical principles to spontaneously align and intercalate among one another, leading to the tissue mass narrowing in one direction and elongating in the orthogonal direction (Zajac et al, 2003;Keller et al, 2008). These cellular rearrangements and tissue reshaping effects are seen in "convergent extension," which establishes the elongated body axis during gastrulation in the amphibian embryo, and related phenomena throughout the Metazoa (Keller, 2002) (POL p ; Fig.…”

Section: Apical-basal and Planar Cell Polarity (The Wnt Pathway)mentioning

confidence: 99%

Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form

Newman¹,

Bhat²

2009

Int. J. Dev. Biol.

167

164

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This article considers the role played by a core set of "dynamical patterning modules" (DPMs) in the origination, development and evolution of complex organisms. These consist of the products of a subset of the genes of what has come to be known as the "developmental-genetic toolkit" in association with physical processes they mobilize. The physical processes are those characteristic of chemically and mechanically excitable mesoscopic systems like cell aggregates: cohesion, viscoelasticity, diffusion, spatiotemporal heterogeneity based on activator-inhibitor interaction, and multistable and oscillatory dynamics. We focus on the emergence of the Metazoa, and show how toolkit gene products and pathways that pre-existed the metazoans acquired novel morphogenetic functions simply by virtue of the change in scale and context inherent to multicellularity. We propose that DPMs, acting singly and in combination with each other, constitute a "pattern language" capable of generating all metazoan body plans and organ forms. This concept implies that the multicellular organisms of the late Precambrian-early Cambrian were phenotypically plastic, fluently exploring morphospace in a fashion decoupled from both function-based selection and genotypic change. The relatively stable developmental trajectories and morphological phenotypes of modern organisms, then, are considered to be products of stabilizing selection. This perspective solves the apparent "molecular homology-analogy paradox," whereby widely divergent modern animal types utilize the same molecular toolkit during development, but it does so by inverting the neo-Darwinian principle that phenotypic disparity was generated over long periods of time in concert with, and in proportion to genotypic change.

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“…These approaches use a cellular Potts model (Graner and Glazier, 1992), stochastic Monte Carlo simulations (Drasdo and Forgacs, 2000), or cellular automata models (Deutsch and Dormann, 2005) and have been applied successfully to several biological phenomena, including convergent extension (Zajac et al, 2003), early cleavage and blastula formation (Drasdo and Forgacs, 2000), and somite border formation (Ying Zhang, personal communication). Together, these modeling efforts have created hypothetical mechanisms that, when constructed in close collaboration with biologists and simulated with biological parameters have produced unique insights and helped direct new experiments (Murray, 1993;Maini et al, 2006).…”

Section: Convergence Of Developmental and Mathematical Biology To Stumentioning

confidence: 99%

From segment to somite: Segmentation to epithelialization analyzed within quantitative frameworks

Kulesa

Schnell

Rudloff

et al. 2007

Developmental Dynamics

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One of the most visually striking patterns in the early developing embryo is somite segmentation. Somites form as repeated, periodic structures in pairs along nearly the entire caudal vertebrate axis. The morphological process involves short-and long-range signals that drive cell rearrangements and cell shaping to create discrete, epithelialized segments. Key to developing novel strategies to prevent somite birth defects that involve axial bone and skeletal muscle development is understanding how the molecular choreography is coordinated across multiple spatial scales and in a repeating temporal manner. Mathematical models have emerged as useful tools to integrate spatiotemporal data and simulate model mechanisms to provide unique insights into somite pattern formation. In this short review, we present two quantitative frameworks that address the morphogenesis from segment to somite and discuss recent data of segmentation and epithelialization.

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Simulating convergent extension by way of anisotropic differential adhesion

Cited by 116 publications

References 37 publications

Shaping the mammalian auditory sensory organ by the planar cell polarity pathway

Shaping the mammalian auditory sensory organ by the planar cell polarity pathway

Dynamical patterning modules: a "pattern language" for development and evolution of multicellular form

From segment to somite: Segmentation to epithelialization analyzed within quantitative frameworks

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