2024
DOI: 10.1101/2024.05.18.594808
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Simulating the Impact of Tumor Mechanical Forces on Glymphatic Networks in the Brain Parenchyma

Saeed Siri,
Alice Burchett,
Meenal Datta

Abstract: Background: The brain glymphatic system is currently being explored in the context of many neurological disorders and diseases, including traumatic brain injury, Alzheimer's disease, and ischemic stroke. However, little is known about the impact of brain tumors on glymphatic function. Mechanical forces generated during tumor development and growth may be responsible for compromised glymphatic transport pathways, reducing waste clearance and cerebrospinal fluid (CSF) transport in the brain parenchyma. One such … Show more

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