Simulation of High Pressure Liquid Chromatography (HPLC) Columns with CFD

Boysen, H.; Wozny, Günter; Lisso, M.; Arlt, Wolfgang; Laiblin, T.

doi:10.1007/978-3-642-55919-8_5

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Domain Geometry and Structure Of The Mesh For The Cfd Simula1

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2003

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“…Due to the nonstructured section for the frit area it is possible to reduce the number of cells in radial direction in the stationary phase. A simulation of the stationary phase with around 40 cells in radial direction is justified, because the gradients in radial direction become more shallow after the distribution [18]. Due to such a grid it is possible to combine the positive characteristics of structured and nonstructured grids.…”

Section: Flow Directionmentioning

confidence: 99%

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CFD Simulation of Preparative HPLC Columns with Consideration of Nonlinear Isotherms

Boysen¹,

Woźny²,

Laiblin³

et al. 2003

Chem Eng & Technol

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The simulation of chromatography increasingly becomes an important tool for process design. For this purpose, one‐dimensional simulations usually are sufficient. For the simulation of today’s preparative HPLC columns with extreme geometries (length/diameter ratio less than 1), at least two dimensions in space have to be considered so that radial influences are taken into account. A two‐dimensional CFD model has been developed using the commercial software FLUENT.

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Section: Flow Directionmentioning

confidence: 99%

“…In this case it is a limiting factor for the accuracy of the calculation. To resolve steep gradients, a dense grid and small time steps are necessary [17,18]. This leads to a considerable demand on calculation time.…”

Section: Domain Geometry and Structure Of The Mesh For The Cfd Simulamentioning

confidence: 99%