Simulation Study of an Impulse Radiation Antenna Array

Li, Chengxiang; Zhao, Y.; Du, Jian; Zhang, Yuanyuan; Mi, Yan; Yao, Chenguo

doi:10.1109/tps.2018.2849851

Cited by 3 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Petrella et al [2018] noted the promising application of a 730 ps, 1016 V/m psPEF in neural stimulation and neural stem cell proliferation. In addition, our simulation work found that picosecond voltage pulse matching an impulse‐radiated antenna could achieve a focus in breast tissue, and when the input was 1 V Gaussian pulse (200 ps in pulse width), the intensity of the focal spots was 62.8 V/m [Li et al, 2018b], which further indicated the promising potential of psPEFs in noninvasive neuromodulation.…”

Section: Introductionmentioning

confidence: 99%

Picosecond Pulse Electrical Field Suppressing Spike Firing in Hippocampal CA1 in Rat In Vivo

Wang

Zhang³

et al. 2020

Bioelectromagnetics

Self Cite

View full text Add to dashboard Cite

Picosecond pulse electrical fields (psPEFs), due to their high temporal-resolution accuracy and localization, were viewed as a potential targeted and noninvasive method for neuromodulation. However, few studies have reported psPEFs regulating neuronal activity in vivo. In this paper, a preliminary study on psPEFs regulating action potentials in hippocampus CA1 of rats in vivo was carried out. By analyzing the neuronal spike firing rate in hippocampus CA1 pre-and post-psPEF stimulation, effects of frequency, duration, and dosimetry of psPEFs were studied. The psPEF used in this study had a pulse width of 500 ps and a field strength of 1 kV/mm, established by 1 kV picosecond voltage pulses. Results showed that the psPEF suppressed spike firing in hippocampal CA1 neurons. The suppression effect was found to be significant except for 10 s, 10 Hz. For shortduration stimulation (10 s), the inhibition rate of spike firing increased with frequency. At longer stimulation durations (1 and 2 min), the inhibition rate increased and decreased alternately as the frequency increased. Despite this, the inhibition rate at high frequencies (5 and 10 kHz) was significantly larger than that at 10 and 100 Hz. A cumulative effect of psPEF on spike firing inhibition was found at low frequencies (10 and 100 Hz), which was saturated when frequency reached 500 Hz or higher. This paper conducts a study on psPEF regulating spike firing in hippocampal CA1 in vivo for the first time and guides subsequent study on psPEF achieving noninvasive neuromodulation. Bioelectromagnetics. 2020;41:617-629.

show abstract

Section: Introductionmentioning

confidence: 99%