Simulation study of reconfigurable surface plasmon resonance refractive index sensor employing bismuth telluride and MXene nanomaterial for cancer cell detection

Abstract

In this study, a highly angular sensitive surface plasmon resonance (SPR) biosensor has been designed for cancer cell detection. The proposed surface plasmon resonance biosensor structure is based on Kretschmann configuration, which works on an angular interrogation technique. The proposed SPR biosensor has enormous possibility to detect the various kind of cancer cells. The refractive index alteration of different cancerous (skin, cervical and blood) cells is 1.360-1.390. The proposed SPR biosensor is stacked with multilayers having CaF2 prism, silver metal, Bi2Te3 and MXene layers. The performance parameters like angular sensitivity, quality factor, detection accuracy, and electric field intensity distribution have been optimized in this article. Here, various kind of cancer cells (skin, cervical and blood) have been also analyzed and corresponding angular sensitives are 252.20, 305.70 and 319.46 deg/RIU respectively. The proposed SPR biosensor shows best results for blood cancer cell detection. Some other important performance parameters like detection accuracy, quality factor, and electric field intensity distribution have also been calculated for proposed SPR biosensor device. The simulation results have been performed by MATLAB 2019a software. The proposed SPR biosensor design may open a new way for the medical industry.

Early detection of Chikungunya virus utilizing the Surface Plasmon Resonance comprising of Silver-Silicon-PtSe 2 Multi-Layer Structure

“…Detection Accuracy (DA) parameter calculates the sensor's exactness. Numerically expressed by [28]: DA = 𝐹𝑊𝐻𝑀 −1 , expressed in Deg −1 , Another parameter that calculates the quality of the sensor is the Figure of merit (FOM) or Quality factor (Q). Mathematically expressed by [29]: 𝐹𝑂𝑀 = 𝑆 .…”

Early Detection of Chikungunya Virus Utilizing the Surface Plasmon Resonance Comprising a Silver-Silicon-PtSe2 Multilayer Structure

“…The detection accuracy (DA) parameter calculates the sensor’s exactness. Numerically expressed by [ 29 ]: (expressed in ). Another parameter that calculates the quality of the sensor is the figure of merit (FOM) or quality factor (Q).…”

Surface plasmonic biosensors: principles, designs and applications

“…Singh et al conducted a simulation study to analyze the SPR sensor and optimized the design using reconfigurable surfaces. 29 The best results of different cancer cells in the assay were analyzed and important performance parameters such as sensitivity and detection accuracy were obtained. This model helps to improve the design efficiency of SPR biosensors and further optimize the performance.…”