Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters

Wang, Jianling; Ye, Jing; Jiang, Hui; Gao, Shengping; Ge, Wei; Chen, Yun; Liu, Chongyang; Amatore, Christian; Wang, Xuemei

doi:10.1039/c4ra05021e

Cited by 26 publications

(19 citation statements)

References 25 publications

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“…Moreover, HAuCl 4 can serve as a precursor without any reducing agent to obtain fluorescent Au NCs under native conditions through in vivo biosynthesis. 19,20 Protein-based protocols hold particular promise, as proteins act as reducing and stabilizing agents that produce water-soluble, biocompatible, and low-toxic 21 NCs under mild reaction conditions. 12 Protein-capped NCs retain their fluorescence (FL) in a wide range of pH and can easily be conjugated with target and drug molecules.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Au nanoclusters for targeted bioimaging and enhanced photodynamic inactivation of Staphylococcus aureus

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Multifunctional Au nanoclusters for targeted bioimaging and enhanced photodynamic inactivation of Staphylococcus aureus

et al. 2015

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“…Zeta potential and dynamic light scattering (DLS) measurements were performed with the Brookhaven Zeta Potential Analyzer. X-ray photoelectron spectroscopy was measured using Thermo Fisher ESCALAB 250Xi X-ray 6 photoelectron spectrometer. For MALDI-time-of-flight (TOF) mass spectrometry (MS) analysis, an AB Sciex 5800 MALDI TOF/TOF analyzer was used with 2,4,6-trihydroxyacetophenone as the matrix.…”

Section: Instrumentationmentioning

confidence: 99%

“…Compared with organic dyes and semiconductor quantum dots (QDs), metal nanoclusters own fantastic features like outstanding photostability, low biotoxicity and good bio-compatibility 5,6 . As the bridge between single atom and nanoparticles, metal nanoclusters have provided a wide area for the development of nanotechnology 7 .…”

Section: Introductionmentioning

confidence: 99%

Lysozyme-stabilized Ag nanoclusters: synthesis of different compositions and fluorescent responses to sulfide ions with distinct modes

Gao

Liu

et al. 2016

RSC Adv.

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In this study, three kinds of red-emitting Ag nanoclusters capped with denatured lysozyme (dLys-AgNCs) were synthesized from different reactant molar ratio of AgNO 3 and lysozyme, called dLys-AgNCs 1, dLys-AgNCs 2 and dLys-AgNCs 3, respectively.The thus synthesized dLys-AgNCs 1 contained only Ag(0), while dLys-AgNCs 2 and dLys-AgNCs 3 contained both Ag(0) and Ag(I). The maximum emission wavelengths of the three dLys-AgNCs were all located near 640 nm when excited at 490 nm, but with different photoluminescence intensity. The photoluminescence properties of these dLys-AgNCs in the presence of common inorganic anions were studied. The three dLys-AgNCs had distinct photoluminescence responding mode to S 2-. The photoluminescence of dLys-AgNCs 1 could be quenched by S 2-, as S 2-destroyed the nanostructure of dLys-AgNCs 1 by forming Ag 2 S. While, the photoluminescence of dLys-AgNCs 3 could be enhanced by S 2-, as S 2-would combine with Ag(I) contained in dLys-AgNCs 3 and altered the ligand-to-metal-metal charge transfer process. For dLys-AgNCs 2, the photoluminescence was enhanced firstly with small amount of S 2-and then quenched with more S 2-added, and this could be due to that S 2-combined with Ag(I) first at low concentration and then with Ag(0) in high concentration. Other anions had no obvious effects except that I -could quench the photoluminescence of these three dLys-AgNCs. The responding mechanisms were further studied by XPS, MS, zeta potential, DLS, and lifetime measurements. Moreover, the as-prepared dLys-AgNCs 1 and dLys-AgNCs 3 were used as fluorescent probe for S 2-

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“…Moreover, Wang's group reported a novel strategy for the self-bioimaging of tumors in vivo through in situ synthesized fluorescent AuNCs based on the fact that the quantity of redox homeostasis is different between cancer cells and normal cells [130]. Lately, based on the above in situ generation method, Wang's group further explored bioimaging of various cancer cells and diseases in vivo [131][132][133][134]. For the purpose of achieving targeted cell imaging, fluorescent AuNCs can be modified with recognition elements.…”

Section: Biological Imagingmentioning

confidence: 99%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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Simultaneous and multisite tumor rapid-target bioimaging through in vivo biosynthesis of fluorescent gold nanoclusters

Abstract: In vivo simultaneous and multisite tumor rapid-targeting through specifically biosynthesized gold nanoclusters could be readily followed and monitored by real-time fluorescence imaging.

Cited by 26 publications

References 25 publications

Multifunctional Au nanoclusters for targeted bioimaging and enhanced photodynamic inactivation of Staphylococcus aureus

Multifunctional Au nanoclusters for targeted bioimaging and enhanced photodynamic inactivation of Staphylococcus aureus

Lysozyme-stabilized Ag nanoclusters: synthesis of different compositions and fluorescent responses to sulfide ions with distinct modes

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

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