The article presents the first clinical case of surgical treatment of a patient with spondylolysis spondylolisthesis using a combination of minimally invasive surgical techniques and simultaneous operation. This intervention has significantly reduced the level of vertebral pain syndrome, improve the functional status in the postoperative period, effectively eliminate pathological mobility, provide early activation, to carry out a full rehabilitation in the shortest possible time and can be an operation of choice in patients with lumbar spondylolysis spondylolisthesis. Conflict of interest: the authors state no conflict ofinterest Funding: the study was performed with no extermal funding