Simultaneous Changes In Muscle Carnosine and Taurine During and Following Supplementation with b-alanine

Harris, Roger C.; Kim, Hyo J; Kim, Chang K.; Kendrick, Ian P.; Price, Karen A.; Wise, John A.

doi:10.1249/01.mss.0000385977.18201.74

Cited by 5 publications

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“…Twenty-six studies were identified in the systematic search and included in the meta-analysis (Harris et al, 2006 , 2010 ; Derave et al, 2007 ; Hill et al, 2007 ; Kendrick et al, 2008 , 2009 ; Baguet et al, 2009 , 2010 ; del Favero et al, 2012 ; Stellingwerff et al, 2012 ; Stegen et al, 2013 ; Bex et al, 2014 , 2015 ; Chung et al, 2014 ; Danaher et al, 2014 ; Gross et al, 2014 ; Kresta et al, 2014 ; Cochran et al, 2015 ; Blancquaert et al, 2017 ; Church et al, 2017 ; Saunders et al, 2017b ; Varanoske et al, 2017 , 2018 ; Black et al, 2018 ; Carvalho et al, 2018 ; da Eira Silva et al, 2020 ). We also included data from two other, currently unpublished, studies conducted within the authors lab.…”

Section: Resultsmentioning

confidence: 99%

The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

et al. 2020

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Section: Resultsmentioning

confidence: 99%

The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

et al. 2020

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“…Both peptide transporter 2 (PEPT2/SLC15A2; Lu and Klaassen 2006;Dieck et al 1999) and the taurine transporter (TauT/SLC616; Tomi et al 2008), have been shown to transport BA in several rodent and cell-culture preparations, but remain to be clearly identified as the primary BA transporter in human skeletal muscle. Correspondingly, a recent conference abstract showed in humans that BA supplementation-induced increases in muscle carnosine resulted in the opposite and compensatory changes in muscle taurine content (Harris 2010). This finding presumably was a result of competitive inhibition of taurine transport by BA, lending support to key role that the taurine transporter (TauT) plays in muscle carnosine and taurine contents in humans.…”

Section: Introductionmentioning

confidence: 99%

Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis

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et al. 2012

Amino Acids

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Interest into the effects of carnosine on cellular metabolism is rapidly expanding. The first study to demonstrate in humans that chronic β-alanine (BA) supplementation (~3-6 g BA/day for ~4 weeks) can result in significantly augmented muscle carnosine concentrations (>50%) was only recently published. BA supplementation is potentially poised for application beyond the niche exercise and performance-enhancement field and into other more clinical populations. When examining all BA supplementation studies that directly measure muscle carnosine (n=8), there is a significant linear correlation between total grams of BA consumed (of daily intake ranges of 1.6-6.4 g BA/day) versus both the relative and absolute increases in muscle carnosine. Supporting this, a recent dose-response study demonstrated a large linear dependency (R2=0.921) based on the total grams of BA consumed over 8 weeks. The pre-supplementation baseline carnosine or individual subjects' body weight (from 65 to 90 kg) does not appear to impact on subsequent carnosine synthesis from BA consumption. Once muscle carnosine is augmented, the washout is very slow (~2%/week). Recently, a slow-release BA tablet supplement has been developed showing a smaller peak plasma BA concentration and delayed time to peak, with no difference in the area under the curve compared to pure BA in solution. Further, this slow-release profile resulted in a reduced urinary BA loss and improved retention, while at the same time, eliciting minimal paraesthesia symptoms. However, our complete understanding of optimizing in vivo delivery and dosing of BA is still in its infancy. Thus, this review will clarify our current knowledge of BA supplementation to augment muscle carnosine as well as highlight future research questions on the regulatory points of control for muscle carnosine synthesis.

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“…Indeed, BA is routinely employed to induce taurine depression in rats [9,11], albeit at far higher relative doses than those employed in human studies, leading to severe health implications and early death [12]. A moderate negative association between intramuscular taurine and carnosine with BA supplementation has been reported in humans [13]. Since we have recently shown that prolonged supplementation with BA results in a chronic downregulation of TauT [3], one could speculate that long-term supplementation may deplete muscle taurine content.…”

Section: Introductionmentioning

confidence: 94%

24-Week β-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males

et al. 2018

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Purpose To investigate the effects of chronic beta-alanine (BA) supplementation on muscle taurine content, blood clinical markers and sensory side-effects. Methods Twenty-five healthy male participants (age 27 ± 4 years, height 1.75 ± 0.09 m, body mass 78.9 ± 11.7 kg) were supplemented with 6.4 g day −1 of sustained-release BA (N = 16; CarnoSyn™, NAI, USA) or placebo (PL; N = 9; maltodextrin) for 24 weeks. Resting muscle biopsies of the m. vastus lateralis were taken at 0, 12 and 24 weeks and analysed for taurine content (BA, N = 12; PL, N = 6) using high-performance liquid chromatography. Resting venous blood samples were taken every 4 weeks and analysed for markers of renal, hepatic and muscle function (BA, N = 15; PL, N = 8; aspartate transaminase; alanine aminotransferase; alkaline phosphatase; lactate dehydrogenase; albumin; globulin; creatinine; estimated glomerular filtration rate and creatine kinase). Results There was a significant main effect of group (p = 0.04) on muscle taurine, with overall lower values in PL, although there was no main effect of time or interaction effect (both p > 0.05) and no differences between specific timepoints (week 0,

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Simultaneous Changes In Muscle Carnosine and Taurine During and Following Supplementation with b-alanine

Cited by 5 publications

References 0 publications

The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

The Muscle Carnosine Response to Beta-Alanine Supplementation: A Systematic Review With Bayesian Individual and Aggregate Data E-Max Model and Meta-Analysis

Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis

24-Week β-alanine ingestion does not affect muscle taurine or clinical blood parameters in healthy males

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