Simultaneous Chiral Analysis of Methamphetamine and Related Compounds by Capillary Electrophoresis/Mass Spectrometry Using Anionic Cyclodextrin

Iio, Reiko; Chinaka, Satoshi; Takayama, Nariaki; Hayakawa, Kazuichi

doi:10.2116/analsci.21.15

Cited by 48 publications

(41 citation statements)

References 16 publications

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“…The different strategies used to avoid the entrance of the chiral selector into the mass analyzer, preventing a deterioration of the sensitivity, were the partial filling of the capillary with the separation media containing the chiral selector in combination with anionic CDs migrating in countercurrent [21,22] or the use of anionic CDs migrating in countercurrent with suppressed EOF [43]. Table 3 reveals that LODs reached in works using EKC-ESI-MS were comprised from 3610 25 to 4610 29 M. Rudaz et al used the countercurrent migration of the negatively charged highly sulfated-g-CD (HS-g-CD) and the partial-filling technique to achieve the enantioseparation of amphetamine derivatives [21,22].…”

Section: End-column Detection In Chiral Analysis By Cementioning

confidence: 99%

“…The use of another anionic CD, the heptakis(2,6-diacethyl-6-sulfato)-b-CD (DAS-b-CD), which moves to the inlet of the capillary and does not flow into the MS detector was used in a selective EKC-ESI-MS method for the simultaneous chiral separation of six drugs [43]. In this work, the EOF was also suppressed by adjusting the pH value of the electrolyte to less than 3.…”

Section: End-column Detection In Chiral Analysis By Cementioning

confidence: 99%

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Sensitive chiral analysis by CE: An update

et al. 2007

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Sensitive chiral analysis by CE: An updateA general view of the different strategies used in the last years to enhance the detection sensitivity in chiral analysis by CE is provided in this article. With this purpose and in order to update the previous review by García-Ruiz et al., the articles appeared on this subject from January 2005 to March 2007 are considered. Three were the main strategies employed to increase the detection sensitivity in chiral analysis by CE: (i) the use of off-line sample treatment techniques, (ii) the employment of in-capillary preconcentration techniques based on electrophoretic principles, and (iii) the use of alternative detection systems to the widely employed on-column UV-Vis absorption detection. Combinations of two or three of the above-mentioned strategies gave rise to adequate concentration detection limits up to 10 210 M enabling enantiomer analysis in a variety of real samples including complex biological matrices.

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Section: End-column Detection In Chiral Analysis By Cementioning

confidence: 99%

Section: End-column Detection In Chiral Analysis By Cementioning

confidence: 99%

Sensitive chiral analysis by CE: An update

et al. 2007

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“…Thus, two different derivatization protocols for amino acids using dansyl chloride (DNS) and FITC were compared observing better mass sensitivity for FITC-amino acids (LODs in the mM range) [139]. CE-ESI-MS has also been used for the sensitive determination of chiral compounds in biological samples such as urine [135,140,141], plasma [142], serum [143], and in vivo samples [144], and for the identification of drugs and their metabolites [145,140].…”

Section: Alternative Detection Systems To On-column Uv-vis Absorptionmentioning

confidence: 99%

Sensitive chiral analysis by capillary electrophoresis

García-Ruiz

Marina

2006

Electrophoresis

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Sensitive chiral analysis by capillary electrophoresisIn this review, an updated view of the different strategies used up to now to enhance the sensitivity of detection in chiral analysis by CE will be provided to the readers. With this aim, it will include a brief description of the fundamentals and most of the recent applications performed in sensitive chiral analysis by CE using offline and online sample treatment techniques (SPE, liquid-liquid extraction, microdialysis, etc.), on-column preconcentration techniques based on electrophoretic principles (ITP, stacking, and sweeping), and alternative detection systems (spectroscopic, spectrometric, and electrochemical) to the widely used UV-Vis absorption detection.

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“…Recently, we have reported highly sensitive methods for MA and its metabolites by CE/MS. 26,27) However, these methods require a procedure of extraction from urine. Therefore, the purpose of this study was to develop a rapid, simple and highly sensitive CE/MS with direct injection of urine for quantifying chiral analysis of seven methamphetamine-related compounds.…”

Section: Introductionmentioning

confidence: 99%