Simultaneous concentration and separation of target compounds from multicomponent mixtures by closed-loop recycling countercurrent chromatography

Kostanyan, A. E.; Мартынова, М. М.; Erastov, A. A.; Белова, В. В.

doi:10.1016/j.chroma.2018.05.032

Cited by 24 publications

(7 citation statements)

References 44 publications

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“…Although the mathematical models on which the theory of the new CLR DM CCC method is based were previously verified experimentally in [9,11,25,28,30,33], it is necessary to carry out further experimental studies for practical implementation of the CLR DM CCC method with specified sample loading durations.…”

Section: Discussionmentioning

confidence: 99%

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Kostanyan

Вошкин

2021

Molecules

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We previously reported on a new counter-current chromatography (CCC) operating mode called closed-loop recycling dual-mode counter-current chromatography (CLR DM CCC), which incorporates the advantages of closed-loop recycling (CLR) and dual-mode (DM) counter-current chromatography and includes sequential separation of compounds in the closed-loop recycling mode with the mobile x-phase and in the inverted-phase counter-current mode with the mobile y-phase. The theoretical analysis of several implementations of this separation method was carried out under impulse sample injection conditions. This study is dedicated to the further development of CLR DM CCC theory applied to preparative and industrial separations, where high-throughput operation is required. Large sample volumes can be loaded via continuous loading within a specified time. To simulate CLR DM CCC separations with specified sample loading durations, equations are developed and presented in “Mathcad” software.

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Section: Discussionmentioning

confidence: 99%

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Kostanyan

Вошкин

2021

Molecules

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“…Based on the ideal recycling approach, equations were developed to describe these CLR CCC separations; different modes of multiple feed injection (the feed is injected in each cycle, after every two cycles, and in an arbitrary cycle) for the separation and concentration of a target component from binary mixtures were studied. In [138], the non-ideal recycling approach was used to develop equations, allowing the design and simulation of different variants of separation and concentration of target compounds from multicomponent mixtures by this method. The principle of the non-ideal recycling approach is schematically shown in Figure 8.…”

Section: Modeling and Design Of Closed-loop Recycling Countercurrent mentioning

confidence: 99%

“…The application of multiple sample injection in the CLR CCC technique provides new opportunities to separate complex mixtures and concentrate target compounds. Examples of the separation of target compounds from three and five-component mixtures are presented in [138].…”

Section: Modeling and Design Of Closed-loop Recycling Countercurrent mentioning

confidence: 99%

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

2020

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Countercurrent liquid-liquid chromatographic techniques (CCC), similar to solvent extraction, are based on the different distribution of compounds between two immiscible liquids and have been most widely used in natural product separations. Due to its high load capacity, low solvent consumption, the diversity of separation methods, and easy scale-up, CCC provides an attractive tool to obtain pure compounds in the analytical, preparative, and industrial-scale separations. This review focuses on the steady-state and non-steady-state CCC separations ranging from conventional CCC to more novel methods such as different modifications of dual mode, closed-loop recycling, and closed-loop recycling dual modes. The design and modeling of various embodiments of CCC separation processes have been described.

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“…Simulation chromatograms obtained by placing detectors before and after the cycle showed that the mathematical description of the concentration distribution was affected. Increasing the extra‐column volume (the recycling line length) caused a time delay of solute's retention but it improved the separation efficiency for CLR CCC process [86,87]. Similar studies were also conducted in closed‐loop recycling and dual‐mode CCC [88,89].…”

Section: Modeling the Dynamic Process Of Counter‐current Chromatographymentioning

confidence: 99%

Recent progress in separation prediction of counter‐current chromatography

Guo

Tong

Zhang

et al. 2020

J of Separation Science

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As a liquid‐liquid partition chromatography, counter‐current chromatography has advantages in large sample loading capacity without irreversible adsorption, which has been widely applied in separation and purification fields. The main factors, including partition coefficient, two‐phase solvent systems, apparatus, and operating parameters greatly affect the separation process of counter‐current chromatography. To promote the applications of counter‐current chromatography, it is essential to develop theoretical research to master the principles of counter‐current chromatographic separations so as to achieve predictions before laborious trials. In this article, recent progress about separation prediction methods are reviewed from a point of the steady and unsteady state of the mass transfer process of counter‐current chromatography and its mass transfer characteristics, and then it is divided into three aspects: prediction of partition coefficient, modeling the thermodynamic process of counter‐current chromatography, and modeling the dynamic process of counter‐current chromatography.

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Simultaneous concentration and separation of target compounds from multicomponent mixtures by closed-loop recycling countercurrent chromatography

Cited by 24 publications

References 44 publications

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Closed-Loop Recycling Dual-Mode Counter-Current Chromatography with Specified Sample Loading Durations: Modeling of Preparative and Industrial-Scale Separations

Analytical, Preparative, and Industrial-Scale Separation of Substances by Methods of Countercurrent Liquid-Liquid Chromatography

Recent progress in separation prediction of counter‐current chromatography

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