Simultaneous Determination of Five Diamide Insecticides in Food Matrices Using Carbon Nanotube Multiplug Filtration Cleanup and Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry

Abstract

In this study, an analytical method was developed and validated for simultaneous determination of five diamide insecticides (chlorantraniliprole, cyantraniliprole, flubendiamide, cyclaniliprole, and tetrachlorantraniliprole) in food matrices. Determination of the latter two diamide compounds is first reported. Samples were cleaned up by multiplug filters containing carbon nanotubes (CNT) or hydrophilic−lipophilic balanced copolymers (HLB) and classic dispersive solid phase extraction (d-SPE) procedures, respectively. The CNT multiplug filter performed the best in terms of process rapidity and cleanup efficiency; thus, it was finally chosen for sample cleanup. Instrumental analysis was completed in 5 min using ultrahigh-performance liquid chromatography−tandem mass spectrometry (UHPLC-MS/MS). Mean recoveries of the five diamides ranged from 84.3 to 110.0%, with intraday and interday relative standard deviations (RSD) of less than 13.5%. Limits of quantitation (LOQ) of all analytes ranged from 0.005 to 0.01 mg kg −1 in different matrices. The results indicate this method is reliable for monitoring the five diamide insecticides in various foods.

Extraction and determination of flubendiamide insecticide in food samples: A review

“…Several adsorbents have been applied to clean-up FBD in sample extracts by SPE such as primary secondary amine (PSA) ( Paramasivam and Banerjee, 2011 ; Mukherjee et al, 2012 ; Chen et al, 2015 ; Słowik-Borowiec and Szpyrka, 2018 ; Sharma et al, 2019 ; Park et al, 2021 ; Reddy et al, 2021 ; Wang et al, 2021 ), activated charcoal ( Sahoo et al, 2009 ; Sharma et al, 2018 ; Takkar et al, 2012 ; Sharma and Parihar, 2013 ), C18 ( Abbas et al, 2017 ; Ares et al, 2017 ; Kabir et al, 2018 ; Kralj et al, 2018 ; Sherma and Rabel, 2018 ; Huh et al, 2019 ; Li et al, 2020 ; Sharma et al, 2019 ; Wang et al, 2021 ), silica gel ( Kabir et al, 2018 ; Sherma and Rabel, 2018 ; Ma et al, 2021 ; Souza et al, 2017 ), Florsil ( Hwang et al, 2018 ; Malhat et al, 2018 ; Słowik-Borowiec and Szpyrka, 2018 ;; Lee et al, 2019 ; Ruiz et al, 2020 ; Kim et al, 2021 ), graphitized carbon black (GCB) ( Lee et al, 2018 ; Słowik-Borowiec and Szpyrka, 2018 ; Wang et al, 2021 ). And hydrophilic-lipophilic balanced (HLB) ( Ballesteros and Ramos-Martos, 2010 ; Abbas et al, 2017 ; Casado et al, 2018 ; Hou et al, 2019 ; Lu et al, 2019 ; Li et al, 2020 ; Jiafeng et al, 2021 ; Park et al, 2021 ). According to reports, HLB is effective for cleaning sample extracts containing pesticides with a wide range of physicochemical properties, ranging from hydrophilic pesticides like FBD to hydrophobic pesticides.…”

Analytical methods to analyze pesticides and herbicides

“…Several diamide insecticides were simultaneously determined by Lu, Zhang, et al (2019) using carbon nanotube (CNT) multiplug filtration cleanup and UHPLC-MS/MS. Compared with hydrophilic-lipophilic balanced copolymers and classic d-SPE procedures, the CNT multiplug filter displayed improved process rapidity and cleanup efficiency.…”

Preparative isolation of the major metabolite NK‐1375 of diamide insecticide cyclaniliprole and its application to pertinent residue analysis in plant‐origin foods using UHPLC–MS/MS

“…CYCP controls pests (mainly Lepidoptera) by activating insect ryanodine receptors, leading to unregulated loss of internal calcium stores, which finally causes muscle paralysis and death (Cordova et al, 2006). Its synthesis (Liu, He, Feng, Yu, & Zhang, 2015), toxicity (EFSA, 2016; JMPR, 2017), and residue analysis method (Lu et al, 2019; Tian et al, 2020) have been widely reported.…”