Simultaneous determination of four different antibiotic residues in honey by chemiluminescence multianalyte chip immunoassays

Wutz, Klaus; Nießner, Reinhard; Seidel, Michael

doi:10.1007/s00604-011-0548-9

Cited by 67 publications

(35 citation statements)

References 37 publications

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“…For this reason, it has been also extensively employed in microfluidic devices, providing superior analytical performance with respect to other optical detection techniques. 6,7 However, in most cases, off-chip detection devices, such as cooled CCDs or photomultipler tubes have been used to detect the emitted light, thus partially compromising the integration level of the device.…”

Section: Chemiluminescence Analytical Chemistrymentioning

confidence: 99%

Performances of amorphous silicon photodiodes integrated in chemiluminescence based μ-TAS

Caputo

Nardini

Scipinotti

et al. 2013

Optical Sensors 2013

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A detailed characterization of the performances of amorphous silicon photodiodes in the detection of chemiluminescent signal is carried out. Comparison with commercial CCD acquisition system has been done as benchmark. The underlying idea is the development of stand-alone and compact micro-total-analysys-systems (µ-TAS) that do not need bulky and expensive equipment for their operation as external focusing optics and excitation sources. The photosensor is p-i-n structures deposited by Plasma Enhanced Chemical Vapour Deposition on a glass substrate covered with a transparent conductive oxide that acts as bottom electrode and window layer for the light impinging through the glass. A PDMS layer with wells has been fabricated using an aluminum mold and bonded on the glass substrate with a well aligned with a photosensor. The experiments have been performed by filling a well with solutions containing different quantities of horseradish peroxidase. A good linearity of the photosensor response is observed across the entire measurement range that spans over three orders of magnitude. The system detection limit is 70 f g/µL. A very good agreement between results achieved with conventional off-chip CCD detection and the on-chip photodiode has been observed. Experiments with target molecules immobilized on a functionalized glass surface have been also performed in microfluidic regime, confirming the validity of the proposed integrated approach based on a-Si:H technology.

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Section: Chemiluminescence Analytical Chemistrymentioning

confidence: 99%

Performances of amorphous silicon photodiodes integrated in chemiluminescence based μ-TAS

Caputo

Nardini

Scipinotti

et al. 2013

Optical Sensors 2013

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“…Therefore, the extraction material (Chromabond 1 Easy) was obtained from Macherey-Nagel (D€ uren, Germany) and was dry packed in a stainless steel column cartridge (30 Â 4.6 mm id). This material is a polar, bifunctionally modified PS/DVB copolymer with a weak anion exchanger, (specific surface 650-700 m 2 g À1 , particle size 80 mm, pore size 50 Å, pH stability [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Before packing, the empty cartridge was cleaned in an ultrasonic methanol bath.…”

Section: Columnsmentioning

confidence: 99%

“…Several methods [12][13][14] have been used for the determination of SDZ in a variety of matrices, most of which are based on liquid chromatography [15][16][17][18][19][20][21]. Most of these methods used in biological matrices such as blood and tissues require solid phase extraction (SPE) and several sample preparation processes, like filtration, deproteinisation, extraction, centrifugation and concentration [22].…”

Section: Introductionmentioning

confidence: 99%

Automated Determination of Sulfadiazine in Water, Fish Plasma and Muscle by HPLC with On‐Line Column‐Switching

Altunok

König

Ahmed

et al. 2016

CLEAN Soil Air Water

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Fast, cheap and simple HPLC methods have been gaining importance in the field of antibiotic residue analysis especially in the context of environmentally friendly and sustainable aquaculture. An effective column-switching technique for HPLC using online extraction column was developed to eliminate the time consuming pretreatment procedures and to facilitate the high throughput analysis of sulfadiazine in fish plasma and muscle as well as in water samples. The standard curves for the determination of sulfadiazine residues from biological matrices and water have good linearity (r 2 > 0.996). The average recovery ranged from 92.2 to 118% with the relative standard deviations of 0.3-9.3%. Limits of detection were determined as 5.7 mg L À1 for water, 8.1 mg L À1 for plasma and 9.6 mg kg À1 for muscle, while limits of quantification were 18.9 mg L À1 for water, 26.9 mg L À1 for plasma and 31.9 mg kg À1 for muscle, respectively. Intra-and inter-day precisions were 0.3-9.3 and 0.4-6.7%, respectively. With the retention time of 12 min and total analysis time less than half an hour, this method provides an effective online extraction process and good sensitivity in liquid chromatography, and can be applied for the determination of residual sulfadiazine in water, fish plasma and muscle at lower than maximum residue level of 100 mg kg À1 fish.

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“…There are very few studies that effectively employ this promising technology for the detection of antibiotics. An immunoassay using the microarray chip reader 3 platform has been described for the determination of antibiotic residues in milk (Kloth et al, 2009a;2009b) and honey (Wutz et al 2011). A novel multiplex nanoarray based on planar waveguide with fluorescence detection was developed for the detection of a number of antibiotics including CAP (McGrath et al, 2015) in milk.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of a novel multispot nanoarray for antibiotic screening in honey

McNamee

Rosar²,

Persic³

et al. 2017

Food Additives & Contaminants: Part A

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Simultaneous determination of four different antibiotic residues in honey by chemiluminescence multianalyte chip immunoassays

Cited by 67 publications

References 37 publications

Performances of amorphous silicon photodiodes integrated in chemiluminescence based μ-TAS

Performances of amorphous silicon photodiodes integrated in chemiluminescence based μ-TAS

Automated Determination of Sulfadiazine in Water, Fish Plasma and Muscle by HPLC with On‐Line Column‐Switching

Feasibility of a novel multispot nanoarray for antibiotic screening in honey

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