Simultaneous determination of N-unsubstituted- and N-substituted nitroazoles and criteria for their identification—I Nitroimidazoles and nitropyrazoles—polarographic determination

Comparison of the voltammetric behavior of metronidazole at a DNA‐modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode

“…Voltammetric studies have shown two reduction waves in acid media for nitroimidazole derivatives, the first wave corresponding to the reduction of the nitro group to form the intermediate hydroxylamine (-NHOH), transferring four electrons and the second wave corresponding to hydroxylamine reduction to amine (-NH,), transferring two electrons. Similar results were obtained for ornidazole [9], but on increasing the pH the second cathodic wave disappeared.…”

Amperometric Metronidazole Sensor Based on the Supermolecular Recognition by Metalloporphyrin Incorporated In Carbon Paste Electrode

“…The reduction of nitroimidazole is a complex process involving the formation of the corresponding amine accompanied by a six-electron transfer [19]. A relatively high applied working potential (> 500 mV) is required in voltammetric studies of these compounds with typical glass carbon or carbon paste electrodes [20,21]. Brett, et.…”

Enantioselective Construction of Aryl‐Substituted All‐Carbon Quaternary Stereocenters by Using Tertiary Amine–Thiourea‐Catalyzed Michael Additions

“…Additionally there is an influence of the HClO 4 concentration on the formation of the cyclodextrins polymers 39. The reduction of nitroimidazole is a complex process in which the nitro group can receive up to six electrons until complete reduction to corresponding amine 40. Under anaerobic conditions or low oxygen pressure, the reduction of nitroimidazole occurs in a similar way to the reduction of nitrobenzene.…”