Simultaneous determination of nineteen compounds of Dahuang zhechong pill in rat plasma by UHPLC-MS/MS and its application in a pharmacokinetic study

Wu, Li; Du, Sha-Li; Yang, Furong; Ni, Zihui; Chen, Zhipeng; Liu, Xiao; Wang, Yulan; Zhou, Qi‐Gang; Li, Weidong; Qin, Kunming

doi:10.1016/j.jchromb.2020.122200

Cited by 12 publications

(5 citation statements)

References 11 publications

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“…According to published accessible investigations ( Chen, Du, Wang, Wu, & Yin, 2022 , Ni et al, 2020 ), 100 components of DHZCP were recognized by the UPLC-HRMS technique in serum or plasma following oral administration to animals, detailed information of which were displayed in Table 1 . Moreover, Wu et al (2020) dissected the pharmacokinetic profiles of 19 active ingredients ( 1 , 2 , 3 , 4 , 5 , 15 , 26 , 28 , 29 , 32 , 39 , 40 , 41 , 52 , 66 , 67 , 80 , 90 , and 114 ) in DHZCP using a highly sensitive UHPLC-QqQ-MS/MS technique and evaluated their characteristic absorption behaviors in vivo , suggesting that DHZCP exerted antitumor effects as a result of the combined and enhanced intervention of multiple effective constituents.…”

Section: Materials Basis Of Dhzcpmentioning

confidence: 99%

Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill

Tian

et al. 2023

Chinese Herbal Medicines

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Section: Materials Basis Of Dhzcpmentioning

confidence: 99%

Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill

Tian

et al. 2023

Chinese Herbal Medicines

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“…The control group consisted of patients who underwent the same interventions without DHZCP or analogous capsules. Specific information on DHZCPs is presented in the Supplementary material (36)(37)(38)(39)(40).…”

Section: Study Characteristicsmentioning

confidence: 99%

A meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy

Huang

She

et al. 2022

Front. Med.

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BackgroundHepatic fibrosis is a health challenge due to the absence of satisfactory therapy, especially at the cirrhosis stage. Dahuang Zhechong pill (DHZCP)-based therapy is reportedly a successful treatment for hepatic fibrosis and is even beneficial for the treatment of cirrhosis. Hence, a systematic review and clinical evidence assessment of DHZCP-based therapy should be performed, and clinical recommendations based on its efficacy for the treatment of hepatic fibrosis should be generated. With respect to potential indicators, the comparative value of the hepatic function, spleen thickness, and portal vein internal diameter should be evaluated.Materials and methodsPubMed, the Excerpta Medica Database, the Cochrane Library, the Web of Science, the WanFang Database, the Chinese Scientific Journal Database, and the Chinese National Knowledge Infrastructure database were searched to identify clinical trials. Three subgroup analyses were performed based on the stage of disease, medication use, and the course of treatment. Statistical analyses were performed using Review Manager 5.4.ResultsA total of 18 studies including 1,494 patients were evaluated. The DHZCP-based therapy was effective in reducing the plasma levels of hyaluronic acid, and laminin, procollagen III, and IV collagen were also reduced irrespective of the hepatitis stage or the presence of hepatic cirrhosis. Abnormalities in alanine aminotransferase, aspartate aminotransferase, albumin, and total bilirubin were reversed. A 6-month course of treatment was the most beneficial DHZCP-based therapy regimen. Alanine aminotransferase improvement was more obvious in patients with cirrhosis, and alanine aminotransferase was reduced significantly in patients with hepatic cirrhosis. With respect to pharmacological mechanisms, DHZCP-based therapy could inhibit hepatic stellate cell growth and activation, reduce inflammation, and prevent extracellular matrix formation. Hepatic portal hypertension and splenomegaly were ameliorated significantly in the DHZCP-based therapy group.ConclusionDahuang Zhechong pill-based therapy has demonstrated efficacy as a treatment for hepatic fibrosis and cirrhosis. A 6-month course of treatment is the recommended option for DHZCP-based therapy in clinical practice. The combination of DHZCP-based therapy and entecavir is a favorable treatment for hepatic cirrhosis.

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“…It is widely used in the modern clinical treatment of hepatitis, cirrhosis and other patients with blood stasis ( Wu et al, 2022 , Zhang and Wang, 2019 ). As one of the classic ancient prescriptions, DHZCP is mainly composed of 12 herbs, including Rhei Radix et Rhizoma (Dahuang in Chinese), Eupolyphaga Steleophaga (Tubiechong in Chinese), Hirudo (Shuizhi in Chinese), Tabanus (Mengchong in Chinese), Paeoniae Radix Alba (Baishao in Chinese), Persicae Semen (Taoren in Chinese), Scutellariae Radix (Huangqin in Chinese), Glycyrrhizae Radix et Rhizoma (Gancao in Chinese) and etc, among which Rhei Radix et Rhizoma (RhRR) and Eupolyphaga Steleophaga (EuS) are recognized as the common monarch drugs ( Wu et al, 2020 ). RhRR has the effect of activating blood circulation in compound DHZCP, while EuS is a blood-breaking drug, and both of them have the synergistic effect of invigorating blood and removing blood stasis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Rhei Radix et Rhizoma and Eupolyphaga Steleophaga on liver protection mechanism based on pharmacokinetics and metabonomics

Feng,

Bi,

Jin

et al. 2024

Chinese Herbal Medicines

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Simultaneous determination of nineteen compounds of Dahuang zhechong pill in rat plasma by UHPLC-MS/MS and its application in a pharmacokinetic study

Cited by 12 publications

References 11 publications

Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill

Clinical antitumor application and pharmacological mechanisms of Dahuang Zhechong Pill

A meritorious integrated medical regimen for hepatic fibrosis and its complications via the systematic review and meta-analysis for Dahuang Zhechong pill-based therapy

Effect of Rhei Radix et Rhizoma and Eupolyphaga Steleophaga on liver protection mechanism based on pharmacokinetics and metabonomics

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