Simultaneous determination of nitrite, nitrate, thiocyanate and uric acid in human saliva by capillary zone electrophoresis and its application to the study of daily variations

Tanaka, Yoshihide; Naruishi, Nahoko; FUKUYA, H; SAKATA, J; Saito, Kimihiko; Wakida, Shin‐ichi

doi:10.1016/j.chroma.2004.06.053

Cited by 32 publications

(19 citation statements)

References 21 publications

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“…Therefore, a simple, rapid, reproducible, and high-throughput determination of the SCN -concentration at low levels in body fluids, water and diverse industrial samples is highly demanded. Various methods, such as spectrometry, 4 spectrofluorometry, 5 Raman spectroscopy, 6 capillary zone electrophoresis, 7 gas chromatography, 8 ion chromatography, 9 photokinetic voltammetry, 10 and amperometry 11 have been reported for thiocyanate determination. Most of these methods are time consuming and involve the use of sophisticated high-cost equipment.…”

Section: Introductionmentioning

confidence: 99%

A Novel Poly(vinyl chloride) Matrix Membrane Sensor for Batch and Flow-Injection Determinations of Thiocyanate, Cyanide and Some Metal Ions

et al. 2009

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Section: Introductionmentioning

confidence: 99%

A Novel Poly(vinyl chloride) Matrix Membrane Sensor for Batch and Flow-Injection Determinations of Thiocyanate, Cyanide and Some Metal Ions

et al. 2009

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“…The concentration of salivary uric acid was estimated to be 92 μM, which is consistent with the salivary uric acid levels reported in the literature. (25) In addition, the diurnal variation of salivary uric acid was measured and the results indicated that the level of salivary uric acid was relatively high in the morning compared with that at night, as shown in Fig. 6(b).…”

Section: Results Of Salivary Uric Acid Measurementmentioning

confidence: 99%

Electrochemical Biosensor for Simplified Determination of Salivary Uric Acid

2018

Sensors and Materials

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A uric acid biosensor aimed at a simplified determination of salivary uric acid was fabricated and utilized for the measurement of the diurnal variation of salivary uric acid. The biosensor measures uric acid as the change in the amount of hydrogen peroxide produced in the uricase reaction. Because uric acid is oxidized as easily as hydrogen peroxide, the osmium-HRP redox reaction was employed. The sensitivity of the biosensor was 170 nA/mM, which was sufficient for salivary uric acid determination. For simplified measurement of a saliva sample, a paperbased saliva sampling device, which enables the sample collection of a regulated amount of saliva in 5 s, was used. As a test using an actual sample, the diurnal variation of salivary uric acid was measured. The result indicated that salivary lactic acid increased in the morning. The total measurement time for the saliva measurement was approximately 3 min, which was sufficiently fast for the purpose of daily health management. The proposed method is expected to be used not only in gout treatment but also possibly in the measurement of other substances contained in saliva.

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“…For example, determination of the sodium and chloride concentrations in sweat may confirm the diagnosis of cystic fibrosis, a life-threatening, autosomal recessive disease (LeGrys 1996(LeGrys , 2007. The level of thiocyanates (cyanide metabolites) in saliva and urine is considered a good test for distinguishing between smokers and non-smokers, and its determination is useful for evaluating smoking behaviour (Bilewicz and Kublik 1981;Giraudi and Grillo 1981;Chinaka 1998;Glatz et al, 2001;Connolly et al, 2002;Themelis and Tzanavaras 2002;Sa´decka´and Polonsky´2003;Chen et al, 2004a, b;Tanaka 2004;Demkowska et al, 2008;Tamosˇiu´nas et al, 2006). The subject literature still lacks information on the determination of these ions in other biological fluids, such as semen and sweat.…”

Section: Introductionmentioning

confidence: 99%

Non-invasive biological fluid matrices analysed to assess exposure to environmental tobacco smoke

Demkowska

Polkowska

Namieśnik

2011

J Expo Sci Environ Epidemiol

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Human biomonitoring (analysis of biological fluids) is increasingly being used for assessing exposure to environmental pollutants. Smoking tobacco is a significant source of indoor air pollution and is harmful to human health. The aim of this research was to find both the best non-invasive matrices (from among saliva, urine, semen and sweat) for evaluating environmental exposure to tobacco smoke and the relationships between thiocyanates (biomarkers of environmental tobacco smoke exposure) and other inorganic ions in these matrices collected from active and passive smokers and also non-smokers.

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Simultaneous determination of nitrite, nitrate, thiocyanate and uric acid in human saliva by capillary zone electrophoresis and its application to the study of daily variations

Cited by 32 publications

References 21 publications

A Novel Poly(vinyl chloride) Matrix Membrane Sensor for Batch and Flow-Injection Determinations of Thiocyanate, Cyanide and Some Metal Ions

A Novel Poly(vinyl chloride) Matrix Membrane Sensor for Batch and Flow-Injection Determinations of Thiocyanate, Cyanide and Some Metal Ions

Electrochemical Biosensor for Simplified Determination of Salivary Uric Acid

Non-invasive biological fluid matrices analysed to assess exposure to environmental tobacco smoke

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