Simultaneous determination of roxithromycin and ambroxol hydrochloride in a new tablet formulation by liquid chromatography

Qi, Meiling; Wang, Peng; Cong, Ruihua; Yang, Jianjun

doi:10.1016/j.jpba.2004.04.001

Cited by 41 publications

(20 citation statements)

References 23 publications

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“…Firstly, four samples of equal size were analyzed at four different heating rates (3,5,7, and 10°C min −1 ) using DSC analyses. A Kissinger plot (Fig.…”

Section: Roxithromycin-chloroform Desolvation Kineticsmentioning

confidence: 99%

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Physicochemical Properties of Amorphous Roxithromycin Prepared by Quench Cooling of the Melt or Desolvation of a Chloroform Solvate

et al. 2012

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ABSTRACT. Roxithromycin is a poorly soluble antibacterial drug. The aim of this study was to prepare and characterize an amorphous form of roxithromycin. The amorphous form was prepared by desolvation of its chloroform solvate, and by quench cooling a melt of the crystalline monohydrated solid. The X-ray powder diffraction pattern of the desolvated chloroform solvate was indistinguishable from that of the glass prepared by melting, which indicated that it was amorphous. The roxithromycin glass was determined to be a fragile glass, but due to its high Kauzmann temperature (approximately 8°C), it should remain fairly stable upon refrigeration or even at room temperature. It was also determined that this glass remains stable in the presence of moisture with no indication of crystallization.

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“…Firstly, four samples of equal size were analyzed at four different heating rates (3,5,7, and 10°C min −1 ) using DSC analyses. A Kissinger plot (Fig.…”

Section: Roxithromycin-chloroform Desolvation Kineticsmentioning

confidence: 99%

“…Roxithromycin is a semi-synthetic 14-membered-ring macrolide antibacterial drug, and it is clinically used for the treatment of respiratory infections caused by Gram-positive and Gram-negative cocci and bacilli, and a variety of other atypical microorganisms (1)(2)(3). The chemical structure of roxithromycin ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Amorphous Roxithromycin Prepared by Quench Cooling of the Melt or Desolvation of a Chloroform Solvate

et al. 2012

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“…They are used for the treatment of upper and lower respiratory tract infections, skin and soft tissue infections and for the prevention and treatment of infections in HIV-positive patients [7], while ROX has a similar antimicrobial spectrum to ERY and is usually used in vivo for the treatment of respiratory infections [16,17]. ROX is characterized by rapid absorption and a long elimination half-time [18].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver – amalgam film electrode

Vajdle

Guzsvány

Škorić

et al. 2017

Electrochimica Acta

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The renewable silver-amalgam film electrode (Hg(Ag)FE) was applied for voltammetric characterization and determination of semi-synthetic macrolide antibiotics azithromycin (AZI), clarithromycin (CLA) and roxithromycin (ROX) in the Britton-Robinson buffer as supporting electrolyte ranging the pH from 4.0 to 11.9. All three macrolides showed reduction signals in fairly negative potential range.During direct cathodic square wave voltammetric (SWV) investigations conducted over the potential range from À0.75 V to À2.00 V vs SCE, either one or two reduction peaks were obtained in the potential range from À1.5 to À1.9 V. The shapes and intensities of the signals depend on the applied pH values in wider pH ranges. For analytical purposes concerning the development of direct cathodic SWV and adsorptive stripping SWV (SW-AdSV) methods the neutral and slightly alkaline media were suitable as pH 7.2, pH 7.4 and pH 7.0 for AZI, CLA and ROX, respectively. Based on the cyclic voltammograms recorded at these pH values, adsorption-controlled electrode kinetics process can be proposed for all three macrolides. Furthermore, the water suppressed 1 H NMR measurements in the pH range between 6.0 and 10.5 indicated that the macrolide molecules at the optimal analytical conditions are predominantly in protonated form via their tertiary amino groups which supported in all three cases their adsorption on the appropriately polarized Hg(Ag)FE electrode. The optimized direct cathodic SWV methods showed good linearity in concentration ranges 4.81-23.3 mg mL À1 , 1.96-28.6 mg mL À1 and 1.48-25.9 mg mL À1 for AZI, CLA and ROX, respectively. The development of the SW-AdSV methods resulted in the linear responses at lower concentration ranges as 1.0-2.46 mg mL À1, 0.05-0.99 mg mL À1 and 0.10-0.99 mg mL À1 , for AZI, CLA and ROX, respectively. The relative standard deviation for all developed methods was not higher than 1.0% except the SWV method for AZI with 4.7%. In the case of all three investigated macrolide antibiotics the protonated form of the tertiary amino group(s) at appropriate accumulation potential and time favored the adsorption of the ionic form of the target molecules offering the opportunity for the development of SW-AdSV methods for their trace level analysis on Hg(Ag)FE. Optimized SW-AdSV method was applied for determination of ROX in pharmaceutical preparation Runac

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“…As for AZT, it has been determined by high performance liquid chromatography (HPLC) [3][4][5][6], liquid chromatography-mass detection (LC-MS/MS) [7,8], ultra-performance liquid chromatography (UPLC) [9], micellar liquid chromatography (MLC) [10], spectroflourimetry [11] and UVVisible spectrophotometry [12][13][14][15][16][17] while ROX has been estimated by HPLC [18,19], LC-MS/MS [20], spectroflourimetry [21,22] and UV-Visible spectrophotometry [23].…”

Section: Introductionmentioning

confidence: 99%

Two spectrophotometric methods for the determination of azithromycin and roxithromycin in pharmaceutical preparations

2017

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Two new and simple spectrophotometric procedures have been proposed and validated for estimation of two important macrolide antibiotics namely, azithromycin dihydrate and roxithromycin. Method I depends on complex formation between any of the two drugs and copper in acidic medium where the absorbances of the produced complexes are measured at 250 and 264 nm with linearity ranges of 1.0-100.0 and 2.0-130.0 µg/mL for the two drugs, respectively. Method II depends on the reaction of these drugs with N-bromosuccinimide forming a product which is yellow colored, measured at 264 and 278 nm, with linearity ranges of 2.0-140.0 and 3.0-160.0 µg/mL for azithromycin dihydrate and roxithromycin, respectively. The proposed methods were subjected to detailed validation procedure; moreover they were used for the estimation of the concerned drugs in their different dosage forms. Study of the reactions stoichiometry was carried out; furthermore, a reaction mechanism proposal was presented.

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Simultaneous determination of roxithromycin and ambroxol hydrochloride in a new tablet formulation by liquid chromatography

Cited by 41 publications

References 23 publications

Physicochemical Properties of Amorphous Roxithromycin Prepared by Quench Cooling of the Melt or Desolvation of a Chloroform Solvate

Physicochemical Properties of Amorphous Roxithromycin Prepared by Quench Cooling of the Melt or Desolvation of a Chloroform Solvate

Voltammetric behavior and determination of the macrolide antibiotics azithromycin, clarithromycin and roxithromycin at a renewable silver – amalgam film electrode

Two spectrophotometric methods for the determination of azithromycin and roxithromycin in pharmaceutical preparations

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