Simultaneous Determination of Thalidomide and Dexamethasone in Rat Plasma by Validated HPLC and HPTLC With Pharmacokinetic Study

Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

“…Most studies that monitor steroid release from vehicles use HPLC or UV-Vis absorbance to quantitate steroid release. HPLC has a reported limit of quantification around 10 nM 50,51 and UV/Vis has a lower detection limit of around 1 µM. 52,53 The reporter cell line we generated utilising an optimally designed promoter for low basal activity and robust activation 32 enabled us to accurately measure dexamethasone concentrations in the range 1 nM to 10 µM.…”

Solid Dosage Forms of Dexamethasone Sodium Phosphate Intended for Pediatric Use: Formulation and Stability Studies

“…On surveying the literature, there are numerous analytical approaches to determine DSP in various samples of biological, animal-derived foodstuffs, etc., in which liquid chromatography (LC), coupled with spectrophotometric (UV) [8] or mass spectrometric detection (MS), is the predominant analytical technique [9][10][11]. Concerning the sample preparation, several efforts have been made to isolate DSP from complicated matrices involving solid phase extraction [12,13], matrix solid phase dispersion [9,14], liquid phase microextraction (LPME) [15], QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) [16,17] and simple protein precipitation [18]. Most of them are laborious, time-consuming and require large amounts of consumables.…”