Simultaneous determination of the four key fluoroquinolones and two antipsychotics in fish and shrimp by LC-MS/MS

Shen, Keyi; Zou, Xiaoshuang; Wang, Jun

doi:10.1080/19440049.2022.2032381

Cited by 9 publications

(3 citation statements)

References 31 publications

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“…Legal requirements need to be supported by proper analytical methods able to ensure efficient control patterns. Several methods are reported in the literature for the screening and quantification of CECs in environmental matrices and food of animal origin [34][35][36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

“…Most of the analytical methods use the liquid chromatography technique interfaced with tandem mass spectrometry detection (LC-MS/MS) for antibiotics quantification. LC-MS/MS, in fact, constitutes the best confirmatory method for the determination of drug residues in food of animal origin [14,38,41]. This work has a double aim: on the one hand, to develop a simple and reliable method of quantifying two commonly used macrolides in mussels; on the other hand, to apply the new method for the investigation of the eventual presence of ERY and AZI in mussels (Mytilus galloprovincialis) harvested in Italy, along the Sardinian coastline, where over 13,000 tons of mussels per year are produced [42].…”

Section: Introductionmentioning

confidence: 99%

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Contaminants of Emerging Concern: Antibiotics Research in Mussels from the Coasts of the Tyrrhenian Sea (Sardinia, Italy)

Dessì,

Varoni,

Baralla

et al. 2024

Animals

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Contaminants of emerging concern (CECs) are compounds found in several environmental compartments whose ubiquitous presence can cause toxicity for the entire ecosystem. Several personal care products, including antibiotics, have entered this group of compounds, constituting a major global threat. It is essential to develop simple and reliable methods by which to quantify these contaminants in several matrices. In this work, mussels were chosen as sentinel organisms to assess environmental pollution and the safety of bivalve mollusk consumption according to the “One Health perspective”. A liquid chromatographic tandem mass spectrometry method (LC-MS/MS) was developed for the quantification of two macrolides, erythromycin (ERY) and azithromycin (AZI), in mussels. This new method was validated according to international guidelines, showing high selectivity, good recoveries (>60% for both of them), sensitivity, and precision. The method was successfully applied for ERY and AZI research in mussels farmed along the Sardinian coasts (Italy), demonstrating itself to be useful for routine analysis by competent authorities. The tested macrolides were not determined in the analyzed sites at concentrations above the limits of detection (LODs). These results demonstrate the food safety of mussels (as concerns the studied antibiotics) and a negligible amount of pollution derived from these drugs in the studied area.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contaminants of Emerging Concern: Antibiotics Research in Mussels from the Coasts of the Tyrrhenian Sea (Sardinia, Italy)

Dessì,

Varoni,

Baralla

et al. 2024

Animals

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“…To date, a variety of detection methods, such as fluorescence [ 7 ], surface-enhanced Raman scattering (SERS) [ 8 ], chemiluminescence detection [ 9 ], capillary electrophoresis (CE) [ 10 ], and high-performance liquid chromatography (HPLC), equipped with a variety of detectors, including ultraviolet (UV) [ 11 ], diode array detection (DAD) [ 12 ], fluorescence (FLD) [ 13 , 14 ], and tandem mass spectrometry (MS/MS) [ 15 , 16 ], have been employed for the determination of QAs. Among these analytical techniques, HPLC-UV instrumentation has been widely used in routine analysis in analytical laboratories.…”

Section: Introductionmentioning

confidence: 99%

Covalent Organic Framework/Polyacrylonitrile Electrospun Nanofiber for Dispersive Solid-Phase Extraction of Trace Quinolones in Food Samples

et al. 2022

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The extraction of quinolone antibiotics (QAs) is crucial for the environment and human health. In this work, polyacrylonitrile (PAN)/covalent organic framework TpPa–1 nanofiber was prepared by an electrospinning technique and used as an adsorbent for dispersive solid-phase extraction (dSPE) of five QAs in the honey and pork. The morphology and structure of the adsorbent were characterized, and the extraction and desorption conditions for the targeted analytes were optimized. Under the optimal conditions, a sensitive method was developed by using PAN/TpPa–1 nanofiber as an adsorbent coupled with high-performance liquid chromatography (HPLC) for five QAs detection. It offered good linearity in the ranges of 0.5–200 ng·mL−1 for pefloxacin, enrofloxacin, and orbifloxacin, and of 1–200 ng·mL−1 for norfloxacin and sarafloxacin with correlation coefficients above 0.9946. The limits of detection (S/N = 3) of five QAs ranged from 0.03 to 0.133 ng·mL−1. The intra-day and inter-day relative standard deviations of the five QAs with the spiked concentration of 50 ng·mL−1 were 2.8–4.0 and 3.0–8.8, respectively. The recoveries of five QAs in the honey and pork samples were 81.6–119.7%, which proved that the proposed method has great potential for the efficient extraction and determination of QAs in complex samples.

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Nanoporous Polyimide Microspheres Solid Phase Extraction Coupled to Liquid Chromatography with Fluorescence Detection to Determine Fluoroquinolones in Water and Food Samples

Zhong

Qiu

et al. 2022

Chromatographia

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Simultaneous determination of the four key fluoroquinolones and two antipsychotics in fish and shrimp by LC-MS/MS

Cited by 9 publications

References 31 publications

Contaminants of Emerging Concern: Antibiotics Research in Mussels from the Coasts of the Tyrrhenian Sea (Sardinia, Italy)

Contaminants of Emerging Concern: Antibiotics Research in Mussels from the Coasts of the Tyrrhenian Sea (Sardinia, Italy)

Covalent Organic Framework/Polyacrylonitrile Electrospun Nanofiber for Dispersive Solid-Phase Extraction of Trace Quinolones in Food Samples

Nanoporous Polyimide Microspheres Solid Phase Extraction Coupled to Liquid Chromatography with Fluorescence Detection to Determine Fluoroquinolones in Water and Food Samples

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