Simultaneous determination of two important dopamine metabolites at physiological pH by voltammetry

Revin, S. Brillians; John, S. Abraham

doi:10.1039/c2ay05664j

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…The interaction between the polymeric backbone and the target analyte was also reported for other heterocyclic conducting polymers, such as 3-amino-5-mercapto-1,2,4-triazole [ 58 , 59 ], polyaniline [ 60 ], and poly-(N-dimethylaniline) [ 61 ].…”

Section: Electronic Tongues (E-tongues) Based On Cpsmentioning

confidence: 77%

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Sierra-Padilla

García-Guzmán

López-Iglesias

et al. 2021

Sensors

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Conducting polymers (CPs) are extensively studied due to their high versatility and electrical properties, as well as their high environmental stability. Based on the above, their applications as electronic devices are promoted and constitute an interesting matter of research. This review summarizes their application in common electronic devices and their implementation in electronic tongues and noses systems (E-tongues and E-noses, respectively). The monitoring of diverse factors with these devices by multivariate calibration methods for different applications is also included. Lastly, a critical discussion about the enclosed analytical potential of several conducting polymer-based devices in electronic systems reported in literature will be offered.

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Section: Electronic Tongues (E-tongues) Based On Cpsmentioning

confidence: 77%

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Sierra-Padilla

García-Guzmán

López-Iglesias

et al. 2021

Sensors

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“…To take the physiological conditions into consideration, pH 7.4 was chosen for the study. Also, DOPAC, which is present in cerebrospinal fluid and blood plasma fluids, is stable only at this pH . Furthermore, the anodic peak potential of DOPAC was shifted to less positive values as the pH values increased.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, determination of their levels in brain is important to study their role in pathology, neurophysiology and behavioral effects and diagnose and control different diseases . 3,4‐Dihydroxy phenyl acetic acid (DOPAC), a metabolite of dopamine, is an important biological molecule and its level in cerebrospinal fluid is an important mark for nigrostriatal degeneration . DOPAC is an important biomarker to demonstrate where the dopamine dysfunction is occurring .…”

Section: Introductionmentioning

confidence: 99%

“…3,4‐Dihydroxy phenyl acetic acid (DOPAC), a metabolite of dopamine, is an important biological molecule and its level in cerebrospinal fluid is an important mark for nigrostriatal degeneration . DOPAC is an important biomarker to demonstrate where the dopamine dysfunction is occurring . As a result, any changes in the concentration of neurotransmitters in the central nervous system would result in many mental and physical disorders such as epilepsy, Alzheimer, Parkinson, schizophrenia and depression .…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of β‐Cyclodextrin/Glycine/Carbon Nanotubes Electrochemical Neurotransmitters Sensor – Application in Ultra‐sensitive Determination of DOPAC in Human Serum

et al. 2018

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In this work, an electrochemical sensor was constructed by applying two successive thin layers of glycine‐carbon nanotubes mixture and β‐cyclodextrin (CNTs‐Gly)/CD over glassy carbon electrode surface for some neurotransmitters determination. A host‐guest interaction between CD and neurotransmitters molecules is expected and resulted in enhanced sensitivity, selectivity and stability of sensor response. Other components of the sensor are crucial for the unique electrochemical response. Carbon nanotubes allowed large surface area for glycine distribution that provided hydrogen bonding to CD moieties and contributed to facilitated charge transfer. It was possible to determine 3,4‐dihydroxy phenyl acetic acid (DOPAC) in the linear range of 0.1 μmol L−1 to 80 μmol L−1 with detection limit of 9.40 nmol L−1, quantification limit of 31.5 nmol L−1 and sensitivity of 4.16 μA/μmol L−1. The proposed sensor was applied in synthetic cerebrospinal fluids samples using random standard addition method. Also, the proposed sensor was used to determine DOPAC in presence of common interferences and acceptable recovery results were achieved for its analysis in real blood serum. Figures of merit for (CNTs‐Gly)/CD composite in terms of precision, robustness, repeatability and reproducibility were reported.

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“…These 2 metabolites are indicators of central dopaminergic activity. 27 The 5-HIAA is a major metabolite of 5HT, and its concentration loss also shows the problem with 5HT metabolism. Although certain other brain regions were also influenced by the oxytocin imprinting—and this shows the extensive effect on the brain—the main targets are the hypothalamus and striatum.…”

Section: Discussionmentioning

confidence: 99%

Effect of a Single Neonatal Oxytocin Treatment (Hormonal Imprinting) on the Biogenic Amine Level of the Adult Rat Brain: Could Oxytocin-Induced Labor Cause Pervasive Developmental Diseases?

et al. 2013

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Perinatal single-hormone treatment causes hormonal imprinting with lifelong consequences in receptor-binding capacity, hormone production as well as in social and sexual behavior. In the present experiments, newborn rats were treated with a single dose of oxytocin, and the levels of biogenic amines and their metabolites were studied in 8 different brain regions and in the sera when the male and female animals were 4 months old. Both dopaminergic and serotonergic neurotransmission was found to be significantly influenced. The levels of 3,4-dihydroxyphenylacetic acid, homovanillic acid, and 5-hydroxyindole acetic acid metabolites decreased in the hypothalamus and striatum. Dopamine, serotonin, norepinephrine, and 5-hydroxytryptophol levels were hardly altered, and there was no difference in the epinephrine levels. The results show that dopamine and serotonin metabolism of hypothalamus and striatum are deeply and lifelong influenced by a single neonatal oxytocin treatment Oxytocin imprinting resulted in decreased dopamine turnover in the hypothalamus and decreased serotonin turnover in the hypothalamus, medulla oblongata, and striatum of females. As the disturbance of brain dopamine and serotonin system has an important role in the development of pervasive developmental diseases (eg, autism) and neuropsychiatric disorders (eg, schizophrenia), the growing number of oxytocin-induced labor as a causal factor, cannot be omitted.

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Simultaneous determination of two important dopamine metabolites at physiological pH by voltammetry

Cited by 8 publications

References 32 publications

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Fabrication of β‐Cyclodextrin/Glycine/Carbon Nanotubes Electrochemical Neurotransmitters Sensor – Application in Ultra‐sensitive Determination of DOPAC in Human Serum

Effect of a Single Neonatal Oxytocin Treatment (Hormonal Imprinting) on the Biogenic Amine Level of the Adult Rat Brain: Could Oxytocin-Induced Labor Cause Pervasive Developmental Diseases?

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