Simultaneous determination of vancomycin and ceftazidime in cerebrospinal fluid in craniotomy patients by high-performance liquid chromatography

A Simple and Modified Method Development of Vancomycin Using High Performance Liquid Chromatography

“…The method was validated with regard to its specificity, linearity, accuracy and sensitivity (within and between days) [20][21][22][23][24][25]. for research purpose of VCM formulation in systemic use.…”

“…The concentrations were calculated from the corresponding calibration standard line (experimental concentrations) and were compared with the theoretical concentrations [32][33][34][35][36][37][38]. The extraction recovery was estimated according to Equation 1 and is shown in Table 2.…”

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“…All these methods present a unique preparatory and chromatographic protocol for single cephalosporin or its metabolite or both of them. Several methods have been used for the analysis of Ceftazidime the third generation cephalosporin for estimation of ceftazidime alone which includes High Performance Liquid Chromatography [26][27][28] and in combination with pyridine 29 Vancomycin 30 and cefepime 31 .…”

Pretreatment of plasma samples by a novel hollow fiber centrifugal ultrafiltrate device for the determination of cefaclor concentrations in human plasma

“…It is well known that removing the proteins is the key step for separation and analysis of drugs in blood samples. Currently, protein precipitation (PPT) [1], liquid-liquid extraction (LLE) [2,3], solid-phase extraction (SPE) [4] and ultrafiltration (UF) [5] are the techniques frequently used for sample preparation.…”