Simultaneous Eeg-Fmri for Preoperative Evaluation in Patients Harboring Pharmacoresistant Epilepsy. Methodology and Clinical Experience

Abstract

Approximately 30% of patients with symptomatic epilepsy have pharmacoresistant seizures refractory to medical therapy. The most effective treatment modality is microsurgical resection of whole epileptogenic zone, not only visible on MRI lesion. However, in some cases patients still have seizures after operation. We provide a method of simultaneous EEG-fMRI to more accurate localization of epileptogenic zone after failed surgery. Here we present our experience of gamma knife stereotactic radiosurgery for patient harboring mesial temporal lobe epilepsy using EEG-fMRI for confirmation of residual epileptogenic zone.