Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

Sciarra, F; Toscano, Vincenzo; Concolino, G; Sorcini, G; Marocchi, Alessandro; Conti, C

doi:10.1159/000178704

Cited by 10 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum T (Sciarra et al, 1976), LH (LH Biodata kit), FSH (FSH Biodata kit) and PRL (F' RL Biodata kit) were measured, in the same assay, by a radioimmunoassay method, F (Murphy, 1967) by a competitive radioassay method.…”

Section: A T E R I a L S A N D M E T H O D Smentioning

confidence: 99%

Influence of Hyperprolactinaemia Due to Metoclopramide on Gonadal Function in Men

Falaschi¹,

Frajese²,

Sciarra³

et al. 1978

Clinical Endocrinology

Self Cite

View full text Add to dashboard Cite

Five clinically normal male volunteers were given metoclopramide, 10 mg t.d.s. for 6 weeks. During treatment prolactin concentrations were elevated (over 50 ng/ml) in all. LH, FSH, testosterone and cortisol concentrations were not altered. No change was observed in LH or FSH responses to LHRH testing 4 weeks after the beginning of therapy, compared with pre-treatment values. A reduction in seminal volume and total sperm count were observed in each subject. Four noticed a decrease in libido and three lost spontaneous erections. While the metoclopramide-induced hyperprolactinaemia could be the cause of the observed changes in semen and erectile activity, it is possible that this dopamine receptor blocking drug might directly affect central or peripheral mechanism of erection, the testes or accessory organs.

show abstract

Section: A T E R I a L S A N D M E T H O D Smentioning

confidence: 99%

Influence of Hyperprolactinaemia Due to Metoclopramide on Gonadal Function in Men

Falaschi¹,

Frajese²,

Sciarra³

et al. 1978

Clinical Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Patients with this complaint, which is of uncertain classification, form a large, heterogeneous group in which dynamic tests or steroid hormonal measurements in the adrenal or ovarian effluent fail to reveal an adrenal or ovarian responsibility for the hirsutism (Ettinger, Goldfiel, Burril, Von Werder & Forsham, 1973;Abraham, Chakmakjan, Buster & Marshall, 1975;Kirschner, Zucker & Jespersen, 1976;Sciarra, Toscano, Concolino, Sorcini, Marocchi & Conti, 1976).…”

Section: Introductionmentioning

confidence: 99%

Is hirsutism an evolving syndrome?

Toscano¹,

Adamo²,

Caiola³

et al. 1983

Journal of Endocrinology

View full text Add to dashboard Cite

The possibility that hirsutism is an evolving syndrome rather than a static condition involving only one gland has been considered. To assess this proposal 60 untreated hirsute patients aged 12-32 years were divided into five groups according to the duration of the hirsutism (less than 1, 1-2, 2-3, 3-5 and greater than 5 years). Peripheral plasma concentrations of LH and FSH, androstenedione, dehydroepiandrosterone sulphate, testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol, cortisol, oestradiol-17 beta and oestrone were determined by radioimmunoassay. When the values obtained were compared with those from normal menstruating women, the results showed that in group I there was a significant increase only in the mean plasma 5 alpha-androstane-3 alpha, 17 beta-diol concentration. The mean concentration of this steroid was also raised in all other groups. In groups II and III mean basal levels of plasma dehydroepiandrosterone sulphate were also significantly increased and showed a marked increase after ACTH stimulation (1 mg tetracosactide acetate, i.m.) as did the concentrations of androstenedione and 17 alpha-hydroxyprogesterone. Finally, in groups IV and V, a significant increase in mean plasma concentrations of LH, androstenedione, oestrone and testosterone was found in the basal condition. The clinical picture also became gradually more severe from group I to group V. These data suggest that hirsutism could be an evolving syndrome progressively involving peripheral androgen metabolism, the adrenal gland and finally the ovary possibly through alterations of hypothalamic-pituitary function.

show abstract