Simultaneous extraction of four different bioactive compounds from Garcinia indica and their enrichment using Aqueous Two-Phase Systems

Nainegali, Basavaraj S.; Iyyaswami, Regupathi; Belur, Prasanna D.

doi:10.1016/j.fbp.2019.01.002

Cited by 20 publications

(13 citation statements)

References 43 publications

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“…Most ATPE techniques have been limited to a particular number of compounds, for instance Nainegali et al [66] obtained four bioactive compounds from Garcinia indica. Other studies on ATPE were limited to a particular kind of bioactive compound.…”

Section: Mass Spectra Of Alkaloid Derivativesmentioning

confidence: 99%

Deciphering the effects of kosmotrope and chaotrope salts during aqueous two phase extraction (ATPE) of polyphenolic compounds and glycoalkaloids from the leaves of a nutraceutical plant, Solanum retroflexum, with the aid of UPLC-QTOF-MS

et al. 2021

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Solanum plants (Solanaceae) are renowned source of nutraceuticals and have widely been explored for their phytochemical constituents. This work investigated the effects of kosmotropic and chaotropic salts on the number of phytochemicals extracted from the leaves of a nutraceutical plant, Solanum retroflexum, and analyzed on the ultra-performance liquid chromatography hyphenated to a quadrupole time of flight mass spectrometer (UPLC-QTOF-MS) detector. Here, a total of 20 different compounds were putatively characterized. The majority of the identified compounds were polyphenols and glycoalkaloids. Another compound, caffeoyl malate was identified for the first time in this plant. Glycoalkaloids such as solanelagnin, solamargine, solasonine, β-solanine (I) and β-solanine (II) were found to be extracted by almost all the salts used herein. Kosmotrope salts, overall, were more efficient in extracting polar compounds with 4 more polyphenolic compounds extracted compared to the chaotropes. Chaotropes were generally more selective for the extraction of less polar compounds (glycoalkaloids) with 3 more extracted than the kosmotropes. The chaotrope and the kosmotrope that extracted the most metabolites were NaCl and Na2SO4, respectively, with 12 metabolites extracted for each salt. This work demonstrated that a comprehensive metabolome of S. retroflexum, more than what was previously reported on the same plant, can be achieved by application of kosmotropes and chaotropes as extractants with the aid of the Aqueous Two Phase Extraction approach. The best-performing salts, Na2SO4 or NaCl, could potentially be applied on a commercial scale, to meet the ever-growing demand of the studied metabolites. The Aqueous Two Phase Extraction technique was found to be efficient in simultaneous extraction of multiple metabolites which can be applied in metabolomics.

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Section: Mass Spectra Of Alkaloid Derivativesmentioning

confidence: 99%

Deciphering the effects of kosmotrope and chaotrope salts during aqueous two phase extraction (ATPE) of polyphenolic compounds and glycoalkaloids from the leaves of a nutraceutical plant, Solanum retroflexum, with the aid of UPLC-QTOF-MS

et al. 2021

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“…Anthocyanins are hydrophilic pigments (Nainegali et al, 2019) that correspond to the purple, red, and blue colors of fruits, vegetables, and plants (Cheynier et al, 2013). These pigments belong to the flavonoid group (Koes et al, 2005).…”

Section: Anthocyaninsmentioning

confidence: 99%

“…According to Chirinos et al (2007), the use of pure (polar) water as solvent can result in extracts with high impurities such as organic acids, sugars, amino acids, and soluble proteins, which may interfere in the identification and quantification of the target components just as ethanol can extract hydrophobic substances (Nainegali et al, 2019). Therefore, there is no single solvent capable of extracting the entire group of phenolic compounds simultaneously (Mokrani & Madani, 2016), which makes using aqueous mixtures with organic solvents in the extraction more efficient (Antolovich et al, 2000).…”

Section: Effect Of Operational Variables On the Extraction Of Phenolic Compoundsmentioning

confidence: 99%

Application of the Box–Behnken experimental design for the extraction of phenolic compounds from araçá‐roxo ( Psidium myrtoides )

Freitas

Rodrigues

Fakhouri

et al. 2021

J. Food Process. Preserv.

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Psidium myrtoides from the Myrtaceae family is endemic to the Atlantic forest but can also be found in the Brazilian caatinga and savanna (Sobral et al., 2015), where it is popularly known as araçároxo. This fruit is characterized by bright globose berries, with several seeds as well as a fleshy and sweet pulp (Lorenzi, 1998), and it is a traditional ingredient of cakes, jams, and jellies (Franzon et al., 2009). Araçá, along with its sweet flavor, contains several important compounds, mainly phenolic, as observed in studies on Psidium cattleia

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“…It was shown that the dried fruit rinds of Garcinia indica contained 2.5 % garcinol while Tryodashang Guggul had 0.701 % and Slimmerz capsules 0.760 % garcinol . With aqueous two‐phase systems (ATPS) containing ethanol and ammonium sulfate garcinol and isogarcinol accumulated in the ethanol phase while anthocyanin and hydroxycitrate built up in the salt‐rich phase . Gold nanoparticles (AuNPs), prepared from G. indica fruit rind extract, showed distinct catalytic activities such as a reduction of toxic 4‐nitrophenol to 4‐aminophenol when combined with NaBH 4 …”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

“…[23] With aqueous two-phase systems (ATPS) containing ethanol and ammonium sulfate garcinol and isogarcinol accumulated in the ethanol phase while anthocyanin and hydroxycitrate built up in the salt-rich phase. [24] Gold nanoparticles (AuNPs), prepared from G. indica fruit rind extract, showed distinct catalytic activities such as a reduction of toxic 4-nitrophenol to 4-aminophenol when combined with NaBH 4 . [25] Distinct progress has also been achieved in the field of the total synthesis of garcinol and isogarcinol.…”

Section: An Update On the Isolation Analysis And Synthesis Of Garcimentioning

confidence: 99%

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Schobert

Biersack

2019

Chemistry & Biodiversity

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The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.

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Simultaneous extraction of four different bioactive compounds from Garcinia indica and their enrichment using Aqueous Two-Phase Systems

Cited by 20 publications

References 43 publications

Deciphering the effects of kosmotrope and chaotrope salts during aqueous two phase extraction (ATPE) of polyphenolic compounds and glycoalkaloids from the leaves of a nutraceutical plant, Solanum retroflexum, with the aid of UPLC-QTOF-MS

Deciphering the effects of kosmotrope and chaotrope salts during aqueous two phase extraction (ATPE) of polyphenolic compounds and glycoalkaloids from the leaves of a nutraceutical plant, Solanum retroflexum, with the aid of UPLC-QTOF-MS

Application of the Box–Behnken experimental design for the extraction of phenolic compounds from araçá‐roxo ( Psidium myrtoides )

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

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