2008
DOI: 10.1016/j.jneumeth.2007.09.005
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Simultaneous glutamate and EEG activity measurements during seizures in rat hippocampal region with the use of an electrochemical biosensor

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Cited by 28 publications
(24 citation statements)
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“…The results obtained here are in accordance with previous data, showing a key role for Glu in seizure generation, whereby an increase in Glu concentration was directly associated with the appearance of the first epileptic burst measured by an electrochemical biosensor [4]. Indeed, a clear rise in Glu concentration was observed when epileptiform activity appeared in the right hippocampus.…”
Section: Discussionsupporting
confidence: 92%
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“…The results obtained here are in accordance with previous data, showing a key role for Glu in seizure generation, whereby an increase in Glu concentration was directly associated with the appearance of the first epileptic burst measured by an electrochemical biosensor [4]. Indeed, a clear rise in Glu concentration was observed when epileptiform activity appeared in the right hippocampus.…”
Section: Discussionsupporting
confidence: 92%
“…Several pathways that use Glu as the principal neurotransmitter have been associated with different neurological diseases such as, schizophrenia, Parkinson's disease, epilepsy and stroke [2][3][4][5]. To understand the role of Glu in both normal circumstances and neurological disorders it is fundamental to be able to precisely measure the levels of this neurotransmitter in brain tissue.…”
Section: Introductionmentioning
confidence: 99%
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“…Serial assessment of the metabolic effects of epileptic phenomena may also be achieved by analyzing microdialysis fluid. GABA, a major inhibitor of neuronal excitation, measured in microdialysate has been found to be increased during seizures in animals [33] and human complex partial seizures [34]. In traumatic brain injury spikes of glutamate reflecting exitotoxicity, [35], glycerol reflecting membrane breakdown, [10], and lactate-pyruvate ratio [11] have been reported.…”
Section: Strategymentioning
confidence: 99%