Introduction: Severe presentation of concomitant carotid, coronary, and peripheral arteriosclerosis is not a common finding. However, some studies have reported surgical and noninvasive interventions for this condition. Case Presentation: Herein, we present a patient with concomitant carotid, coronary, and peripheral arteriosclerosis, who underwent angioplasty in Tehran, Iran in November 2015. Some studies have been carried out on surgical and percutaneous coronary, carotid and peripheral intervention for concomitant lesions; however, reports about percutaneous coronary, carotid and peripheral intervention, similar to the present case, are not available. Conclusions: Due to lack of evidence on the prevalence and management of concomitant multifocal coronary, carotid, and limb arteriosclerosis, it is necessary to perform well-designed studies on such groups of patients to define proper management (surgical versus endovascular interventions), periprocedural complications, as well as short-and long-term outcomes.