Simultaneous immunohistochemical expression of HBME‐1 and galectin‐3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid

Abstract

An immunohistochemical panel consisting of HBME-1 and galectin-3 can make a correct distinction between malignant and hyperfunctioning thyroid neoplasms with high diagnostic accuracy.

Utility of malignancy markers in fine-needle aspiration cytology of thyroid nodules: comparison of Hector Battifora mesothelial antigen-1, thyroid peroxidase and dipeptidyl aminopeptidase IV

“…A number of other molecules have been described later on as malignancy markers for thyroid carcinoma. Three of them, that is, HBME-1, galectine-3 (GAL3), and cytokeratine-19 (CK19), have been tried on cytological material and are considered useful (van Hoeven et al, 1998;Saggiorato et al, 2005;Rossi et al, 2006). However, almost all these studies were performed on cell blocks or thin-prep samples because of poor results on conventional smears.…”

“…The reported specificity of HBME-1 staining ranged from 70% to more than 90% (Cheung et al, 2001;Prasad et al, 2005;Saggiorato et al, 2005). Thyrotoxic hyperplasia was consistently negative (Rossi et al, 2006) whereas nodular goitres were positive in up to 17% of cases (Ito et al, 2005). Significant reactions were also reported in 25% of thyroiditis (Prasad et al, 2005), 5 -10% of benign follicular tumours devoid of atypical features, and up to 65% with LNFPTC or Hürthle cell features (Mai et al, 2002;Papotti et al, 2005;Prasad et al, 2005;Scognamiglio et al, 2006).…”

Expression of Cytokeratin 19 and Protein p63 in Fine Needle Aspiration Biopsy of Papillary Thyroid Carcinoma

“…CK19 has been found to be strongly expressed in PTC in both cytologic and tissue specimens. 6,7,11,[15][16][17] In our study, 81% of FNABs from PTC and 93% of the corresponding histologic specimens showed strong and diffuse CK19 positivity. However, CK19 was strongly expressed in FNAB smears of 4 adenomas, 1 Hashimoto's thyroiditis and 1 nodular goiter and in histologic specimens of 1 adenoma, 1 Hashimoto's thyroiditis, 7 Hashimoto's thyroiditis concurrent with PTC and 1 nodular goiter.…”

“…8,9,13 Moreover, this marker has been reported to be useful in cytologic smears and in cell block preparations for the diagnosis of PTC. [15][16][17] p53-Homologous nuclear protein p63 (p63) has been recently described for use in papillary thyroid carcinoma, [18][19][20][21][22] but to the best of our knowledge, p63 expression in FNAB of the thyroid has not been investigated before.…”

Paired box gene 8, HBME‐1, and cytokeratin 19 expression in preoperative fine‐needle aspiration of papillary thyroid carcinoma

“…10,11 Its utility in thyroid carcinomas has been documented in several studies, revealing strong and diffuse cytoplasmic staining in PTCs. [12][13][14][15][16][17] It is considered the most specific marker (96%) for PTC by some authors, and the most sensitive and specific marker by others, reportedly staining 96% of PTCs and only 7% of BTN cases. 12,13 Other studies have demonstrated that immunoreactivity for HBME-1 is an indication of thyroid malignancy, but not necessarily of papillary differentiation.…”