This paper discusses the impact of Fischer-Tropsch (F-T) diesel and methanol blended fuel, tentative engine was operated with fueled having F-T diesel and methanol blended fuel to compare the combustion and vibration characteristics. For this, 4100QBZL turbocharged diesel having parameters of F-T diesel fuel, FM5, FM10, FM15 methanol volume content was 5%, 10%, and 15%, respectively, have been selected for the experiment. Experimental studies have shown that when fueling with F-T diesel fuel, the ignition delay is shorter, the premixed combustion rate peak is lower, and vibration acceleration increases slightly than diesel fuel. Compared to the pure F-T diesel, the blended fuel has longer ignition delay period, higher the rate of pressure rise, combustion start point delayed, burning capacity increase, such as thermal efficiency is improved and vibration acceleration increased significantly.