Simultaneous occurrence of splenic diffuse large B cell lymphoma and gastrointestinal stromal tumor in the stomach: a case report

Abstract

BackgroundAlthough the primary malignant spleen tumor is relatively rare, lymphoma is the most common splenic malignancy. It can have quite different clinical manifestations that usually lead to relatively poor outcomes, and thus early and accurate diagnosis are of utmost importance.Case presentationThe present study reports a case of a 67-year-old female with high fever, abnormal spleen (diagnosed by PET/CT) and no obvious lymph node enlargement. After being subjected to splenectomy, the patient was diagnosed with splenic diffuse large B cell lymphoma coexisting with gastrointestinal stromal tumor in the stomach.ConclusionsTo our knowledge, splenic lymphoma accompanied by gastrointestinal stromal tumor in the stomach is rarely reported. This case report discusses the diagnosis and case management of a patient referring to the existing literature.

Characteristics and survival outcomes of primary splenic cancers

“…Second, several important variables that may impact affect prognosis are not included in this study. For example, it was reported that splenic cancer may have different clinical manifestations but these were simply reported as abdominal discomfort or spleen enlargement without any other abnormalities [10,27] . Third, abnormal blood counts neutropenia, decreased hemoglobin, thrombocytopenia, or lymphocytosis can also be found through laboratory examinations [15] .…”

“…For example, it was reported that splenic cancer may have different clinical manifestations but these were simply reported as abdominal discomfort or spleen enlargement without any other abnormalities. [10,27] Third, abnormal blood counts neutropenia, decreased hemoglobin, thrombocytopenia, or lymphocytosis can also be found through laboratory examinations. [15] Elevated lactate dehydrogenase levels also can be seen in patients with splenic lymphoma that also correlate with a worse prognosis.…”