Simultaneous quantification of 22R and 22S epimers of budesonide in human plasma by ultra-high-performance liquid chromatography–tandem mass spectrometry: Application in a stereoselective pharmacokinetic study

Lu, Youming; Sun, Zuoming; Zhang, Yifan; Chen, Xiaoyan; Zhong, Dafang

doi:10.1016/j.jchromb.2013.01.015

Cited by 17 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stereo-selective pharmacokinetic studies are open conducted because most drugs are administered as a mixture of stereoisomers [12,13,14,15,16]. The effects of stereo-specificity on the pharmacokinetics of drugs may be due to stereo-selective metabolism and/or distribution, including absorption.…”

Section: Discussionmentioning

confidence: 99%

“…Paclitaxel [12] and 25-methoxyl-dammarane-3β,12β,20(R/S)-triol [13] are good examples of drugs that show enantio-selective metabolism related to their configurations at the 7-carbon and 20-carbon positions, respectively. The systemic exposure of 22 R -budesonide is six-fold less than that of the 22 S form due to their enantio-specific distribution [14]. The R -epimers of the ginsenoside analogues Rh2 and Rg3 are poorly absorbed compared to the S -isomers, possibly due to their lower membrane permeability and extensive intestinal biotransformation [15].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats

et al. 2019

View full text Add to dashboard Cite

An ilimquinone (IQ) mixture isolated from Hippiospongia metachromia, consisting of IQ and epi-ilimaquinone (epi-IQ), exerts anti-HIV, anti-microbial, anti-inflammatory, and anti-cancer effects. An HPLC-MS/MS method was developed for simultaneous determination of the two epimers in rat plasma, separating them using a biphenyl column. Ascorbic acid is added during the sample preparation to ensure the stability of both isomers. The plasma concentrations of the isomers were monitored following intravenous and oral administration of the IQ mixture in rats as well as the individual epimers that were separately orally administered. Compare to IQ, epi-IQ was much more stable in rat plasma, likely due to its configurations of decalin. Both substances decayed in more than bi-exponential pattern, with an elimination rate constant of 1.2 h−1 for IQ and 1.7 h−1 for epi-IQ. The epi-IQ was distributed more widely than IQ by about two-fold. Consequently, the clearance of epi-IQ was greater than that of IQ by about three-fold. The oral absolute bioavailability for IQ was 38%, and, that for epi-IQ, was 13%. Although the systemic exposure of IQ was greater than that of epi-IQ by ~8.7-fold, the clearance of each isomer was similar when administered either orally or intravenously, when normalized for bioavailability. The stereo-specific behavior of the isomers appears to originate from differences in both their tissue distribution and gastrointestinal permeability.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The method was validated for selectivity, linearity, accuracy, precision, recovery and stability according to the literatures (Lu et al ., ; Wang et al ., ) for validation of bioanalytical methods (US Food and Drug Administration, ). Validation runs were conducted on three consecutive days.…”

Section: Methodsmentioning

confidence: 99%

Determination of chidamide in rat plasma by LC‐MS and its application to pharmacokinetics study

Wang

Chen

Wen

et al. 2013

Biomedical Chromatography

View full text Add to dashboard Cite

A sensitive and selective liquid chromatography mass spectrometry method for determination of chidamide in rat plasma was developed. After addition of linezolid as internal standard, protein precipitation by acetonitrile-methanol (9:1, v/v) was used as sample preparation. Chromatographic separation was achieved on a Zorbax SB-C18 (2.1 × 150 mm, 5 µm) column with acetonitrile-0.1% formic acid as mobile phase with gradient elution. An electrospray ionization source was applied and operated in positive ion mode; selective ion monitoring mode was used for quantification using target fragment ions m/z 391.5 for chidamide and m/z 338.5 for the IS. Calibration plots were linear over the range of 10-2000 ng/mL for chidamide in rat plasma. The lower limit of quantification for chidamide was 10 ng/mL. The mean recovery of chidamide in plasma was in the range of 86.6-92.1%. The coefficients of variation of intra-day and inter-day precision were both <12%. This method is simple and sensitive and was applied successfully in a pharmacokinetic study of chidamide to rats.

show abstract

“…Formoterol fumarate is a bronchodilator that dilates the bronchi and bronchioles, decreases resistance in the respiratory airway, increases airflow to the lungs, and is used in the treatment of asthma. [1][2][3]…”

Section: Introductionmentioning

confidence: 99%

Validation of In-vitro Deposition of Emitted Dose Method for Simultaneous Estimation of Formoterol Fumarate and Glycopyrrolate in combined Dry Powder Inhaler Aerosol Pharmaceutical Dosage Form

Kotak

Pandya

2020

Int. J. Pharm. Sci. Drug Res.

View full text Add to dashboard Cite

Formoterol Fumarate and Glycopyrrolate Dry powder inhaler is combined aerosol dosage form. The label claim of this combined dosage form is 25 mcg of Glycopyrrolate and 6 mcg of Formoterol Fumarate per respicap. It is prescribed for treatment of Asthma and COPD. Formoterol Fumarate is anti asthmatic drug (Bronchodilator) and Glycopyrrolate is quaternary ammonium compounds which is Anticholinergic Drug. A bronchodilator is a substance that dilates the bronchi and bronchioles, decreasing resistance in the respiratory airway and increasing airflow to the lungs while Glycopyrrolate blocks muscarinic receptors thus inhibiting cholinergic transmission. Glycopyrrolate is also known as Glycopyrronium Bromide, an Anticholinergic agent. It is used to inhibit salivation and excessive secretions of the respiratory tract preoperatively; reversal of neuromuscular blockade; control of upper airway secretions; and part of treatment for peptic ulcer. The present study aimed to Validate HPLC method for determination of Deposition of emitted dose of Formoterol Fumarate and Glycopyrrolate Analytes. This study covers Precision, Linearity, Accuracy, Robustness, Ruggedness, stability of analytical solution and Specificity. The chromatographic method uses a reversed phase column Purosphere star RP 18e (125 mm × 4.6 mm x 5 μm). The mobile phase was prepared by mixing Buffer : Acetonitrile : Methanol (68 : 24 : 8 %v/v/v) at flow rate 1.0 ml per min with UV and PDA detector 215 nm, column oven adjusted to 25° C with injection volume 100 μL. The method showed a successful application for determination of Formoterol Fumarate and Glycopyrrolate in Dry powder inhaler pharmaceutical formulation.

show abstract

Simultaneous quantification of 22R and 22S epimers of budesonide in human plasma by ultra-high-performance liquid chromatography–tandem mass spectrometry: Application in a stereoselective pharmacokinetic study

Cited by 17 publications

References 17 publications

Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats

Stereo-Selective Pharmacokinetics of Ilimaquinone Epimers Extracted from a Marine Sponge in Rats

Determination of chidamide in rat plasma by LC‐MS and its application to pharmacokinetics study

Validation of In-vitro Deposition of Emitted Dose Method for Simultaneous Estimation of Formoterol Fumarate and Glycopyrrolate in combined Dry Powder Inhaler Aerosol Pharmaceutical Dosage Form

Contact Info

Product

Resources

About