Simultaneous quantification of artesunate and mefloquine in fixed-dose combination tablets by multivariate calibration with middle infrared spectroscopy and partial least squares regression

Marson, Breno Maurício; Vilhena, Raquel de Oliveira; Madeira, Camilla Regina de Souza; Pontes, Flávia Lada Degaut; Piantavini, Mário S.; Pontarolo, Roberto

doi:10.1186/s12936-016-1157-1

Cited by 10 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PLS was applied for the simultaneous quantitative determination of paracetamol and tramadol in paracetamol-tramadol tablets (108) and for the analysis of a binary mixture tablet containing bisoprolol fumarate and hydrochlorothiazide (109) from UV spectrophotometric data. A method based on diffuse reflectance, middle infrared spectroscopy and PLS was used for simultaneous quantification of artesunate and mefloquine in tablets (110).…”

Section: Application Of Artificial Neural Network and Multivariate Data Analysis As Complementary Tools In Pharmaceutical Developmentmentioning

confidence: 99%

Quality-by-design in pharmaceutical development: From current perspectives to practical applications

et al. 2021

View full text Add to dashboard Cite

Current pharmaceutical research directions tend to follow a systematic approach in the field of applied research and development. The concept of quality-by-design (QbD) has been the focus of the current progress of pharmaceutical sciences. It is based on, but not limited, to risk assessment, design of experiments and other computational methods and process analytical technology. These tools offer a well-organized methodology, both to identify and analyse the hazards that should be handled as critical, and are therefore applicable in the control strategy. Once implemented, the QbD approach will augment the comprehension of experts concerning the developed analytical technique or manufacturing process. The main activities are oriented towards the identification of the quality target product profiles, along with the critical quality attributes, the risk management of these and their analysis through in silico aided methods. This review aims to offer an overview of the current standpoints and general applications of QbD methods in pharmaceutical development.

show abstract

Section: Application Of Artificial Neural Network and Multivariate Data Analysis As Complementary Tools In Pharmaceutical Developmentmentioning

confidence: 99%

Quality-by-design in pharmaceutical development: From current perspectives to practical applications

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Previous studies on near IR with partial least squares regression (PLSR) models were developed for the determination of artesunate and azithromycin in co-formulation of hard gelatin capsule [ 19 ] and fix-dose combination of anti-tuberculosis tablets (rifampin, isoniazid, pyrazinamide and ethambutol) [ 20 ]. FTIR with PLSR pretreated raw data by first derivative and Savitzky–Golay smoothing followed by mean centring was employed for the quantitative analysis of combined anti-malaria formulations of artesunate and mefloquine [ 21 ]. In addition, Raman spectroscopy with principal component regression (PCR) was employed to quantify dipyrone (metamizole) in oral solutions [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Chemometrics-assisted spectroscopic methods for rapid analysis of combined anti-malarial tablets

Pruksapha,

Khongkaew,

Suwanvecho

et al. 2023

Journal of Food and Drug Analysis

View full text Add to dashboard Cite

Combination of piperaquine (PQ) (320mg) and dihydroartemisinin (DHA) (40 mg) is an anti-malarial formulation, which is recommended by World Health Organization (WHO). Simultaneous analysis of PQ and DHA can be problematic due to the lack of chromophores or fluorophores in DHA molecule. Whereas PQ possesses strong UV absorption and it presents in 8 times of DHA contents in the formulation. In this study, two spectroscopic methods, Fourier transform infrared (FTIR) and Raman spectroscopy, were developed for the determination of both drugs in combined tablets. The FTIR and Raman spectra were recorded in the attenuate total reflectance (ATR) and scattering modes, respectively. The original and pretreated spectra from FTIR and handheld-Raman were subjected to Unscrambler® program to construct partial least squares regression (PLSR) model comparing with references values obtained from high performance liquid chromatography (HPLC)-UV method. The optimal PLSR models of PQ and DHA from FTIR spectroscopy were obtained from orthogonal signal correction (OSC) pretreatment at the wavenumbers 400—1,800 cm −1 and 1,400—4,000 cm −1 , respectively. For Raman spectroscopy of PQ and DHA, the optimal PLSR models were obtained from standard normal variate (SNV) pretreatment at the wavenumbers 1,200—2,300 cm −1 and OSC pretreatment at the wavenumber 400—2,300 cm −1 , respectively. Determination of PQ and DHA in tablets from the optimum model was compared with HPLC-UV method. Results were not significantly different at 95% confidence limit ( p -value >0.05). The chemometrics-assisted spectroscopic methods were fast (1–3 min), economical and less labor intensive. Moreover, the handheld Raman spectrometer is portable and can be utilized for onsite analysis to facilitate the detection of counterfeit or substandard drugs at ports of entry.

show abstract

“…The benefits of an alternative analytical method include but are not limited to; an easier method for preparation, a more specific means for of analysis, lower costs, faster analysis, methods that are more environmentally friendly, and can provide results with better accuracy and precision. Simultaneously qualitative and quantitative analysis by Fourier Transform Infrared has already been successfully implemented in several areas of industrial pharmacy (Marson et al, 2016). The Fourier Transform Infrared is simple, specific, cheap, fast, and a green method.…”

Section: Introductionmentioning

confidence: 99%

Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form

Nerdy

Margata

Meliala

et al. 2021

Valensi

View full text Add to dashboard Cite

The first line drug given for monotherapy for diabetes mellitus type 2 is metformin hydrochloride, which is a biguanide antihyperglycemic drug. The aim of this research was to develop, validate, and apply the Fourier Transform Infrared spectrophotometry method to identify and determine metformin hydrochloride in marketed tablet dosage form. This research included preparation of standard, analysis of samples, and validation of method. The specific wavenumber obtained for qualitative analysis was 1645.68 cm–1 and 1574.8 cm–1. The specific area obtained for quantitative analysis with a single baseline ranged from 1701.53 cm–1 to 1535.66 cm–1. All metformin hydrochloride marketed tablet dosage forms were analyzed and met all of the qualitative and quantitative requirements. The methods met the requirements of method validation for accuracy with a percentage of recovery of 100.22 %, precision with relative standard deviation of 0.48 %, linearity with a correlation coefficient of 0.9992, limit of detection of 11.17 mg per mL, limit of quantitation of 33.84 mg per mL, and good specificity results. In this study, the Fourier Transform Infrared spectrophotometry method was successfully developed and validated for application in identification and determination of metformin hydrochloride in marketed tablet dosage form.

show abstract

Simultaneous quantification of artesunate and mefloquine in fixed-dose combination tablets by multivariate calibration with middle infrared spectroscopy and partial least squares regression

Cited by 10 publications

References 18 publications

Quality-by-design in pharmaceutical development: From current perspectives to practical applications

Quality-by-design in pharmaceutical development: From current perspectives to practical applications

Chemometrics-assisted spectroscopic methods for rapid analysis of combined anti-malarial tablets

Application of Fourier Transform Infrared Spectrophotometry Method for Analysis of Metformin Hydrochloride in Marketed Tablet Dosage Form

Contact Info

Product

Resources

About