Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography

Li, Na; Lin, Ge; Kwan, Yiu Wa; Min, Zhi-Da

doi:10.1016/s0021-9673(99)00600-7

Cited by 121 publications

(69 citation statements)

References 19 publications

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“…Among the four crocins, crocin 1 or α-crocin is the most abundant in saffron and has been extensively studied for its antioxidant activity by quenching free radicals and protecting cells and tissues against oxidation. Besides, other minor carotenoids are also present in saffron such as carotenes, lycopene, zeaxanthin, mangicrocin and xanthone-carotenoid glycosidic conjugate (Licon et al 2012;Maggi et al 2011;Bathaie and Mousavi 2010;Hadizedeh et al 2010;Asai et al 2005;Li et al 1999). picrocrocin (C 16 H 26 O 7 ) which is a colorless glycoside and product of zeaxanthin degradation and is the main substance responsible for the bitter taste of saffron.…”

Section: Saffron Chemistrymentioning

confidence: 99%

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

et al. 2014

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Saffron (Crocus sativus L. stigma), the most valuable medicinal food product, belongs to the Iridaceae family which has been widely used as a coloring and flavoring agent. These properties are basically related to its crocins, picrocrocin and safranal contents which have all demonstrated health promoting properties. The present review article highlights the phytochemical constituents (phenolic and flavonoid compounds, degraded carotenoid compounds crocins and crocetin) that are important in antioxidant activity of saffron extracts. However, the synergistic effect of all the bioactive components presence in saffron gave a significant antioxidant activity similar to vegetables rich in carotenoids. Our study provides an updated overview focused on the antioxidant activity of saffron related to its bioactive compounds to design the different functional products in food, medicine and cosmetic industries.

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Section: Saffron Chemistrymentioning

confidence: 99%

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

et al. 2014

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“…In general, HPLC can be used to analyze almost all the compounds in the herbal medicines. Thus, over the past decades, HPLC has received the most extensive application in the analysis of herbal medicines [63][64][65][66][67][68][69][70][71][72][73][74][75][76]. Reversed-phase (RP) columns may be the most popular columns used in the analytical separation of herbal medicines.…”

Section: High-performance Liquid Chromatographymentioning

confidence: 99%

Quality control of herbal medicines

Liang¹,

Xie²,

Chan³

2004

Journal of Chromatography B

499

401

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Different chromatographic and electrophoretic techniques commonly used in the instrumental inspection of herbal medicines (HM) are first comprehensively reviewed. Chemical fingerprints obtained by chromatographic and electrophoretic techniques, especially by hyphenated chromatographies, are strongly recommended for the purpose of quality control of herbal medicines, since they might represent appropriately the "chemical integrities" of the herbal medicines and therefore be used for authentication and identification of the herbal products. Based on the conception of phytoequivalence, the chromatographic fingerprints of herbal medicines could be utilized for addressing the problem of quality control of herbal medicines. Several novel chemometric methods for evaluating the fingerprints of herbal products, such as the method based on information theory, similarity estimation, chemical pattern recognition, spectral correlative chromatogram (SCC), multivariate resolution, etc. are discussed in detail with examples, which showed that the combination of chromatographic fingerprints of herbal medicines and the chemometric evaluation might be a powerful tool for quality control of herbal products.

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“…The studies have displayed that saffron's extract has anti tumorous (Abdullaev and Espinosa-Aguirre, 2004) and anti mutation (Fernandez, 2004) properties and prevents the nucleic acid synthesis in malignant cells on humans (Abdullaev and Ferenkel, 1992;Mohajeri et al, 2008;Nair et al, 1995). Saffron's extract has various compounds like α-Krustyn, crocins including the crocin and tricrocin, pykrvkrvsyn and safranal (Alonso et al, 1998;Li et al, 1999;Lozano et al, 2000;Tarantilis et al, 1994;. These carotenoids protective effect on variety of cancers and preventing exhaustion of neurons and enhancing the memory have been studied (Ochiai et al, 2007;2004) but there has been insufficient attention to physiologic or side effects of saffron's extract on reproductive system function (Fernandez, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

2011

American Journal of Animal and Veterinary Sciences

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Problem statement: Saffron is widely used as a food flavor and has well known medicinal effects. This drug has an effect on steroid and sexual hormones. The aim of this study was investigation of Saffron orally administration on histomorphometric change of testicular tissue in rat. In this experimental study, 40 male rats are used (4 groups and 10 rats in each group). Approach: Animals were received Saffron (50, 100 and 200 mg kg −1 ) daily orally administration, during 28 days. As one group was control (normal saline) and three groups was drug consumer. The testis tissue was sampled after passing of above time and section providing, was stained by H and E. Results: The histomorphometric changes of testicular tissue which include, seminiferous tubules diameter, seminiferous epithelial thickness, interstitial tissue and testicular capsule thickness were studied. Results showed that seminiferous tubules diameter, seminiferous epithelial thickness had significantly decreased (p<0.05) but interstitial tissue thickness had significantly increased (p<0.05) compared with control group. Testicular capsule thickness had not significantly changed. Conclusion: Our results showed that seminiferous tubules diameter, seminiferous epithelial thickness and interstitial tissue thickness in rat testis were significantly changed after Saffron orally administration. This results probably via the reducing of serum testosterone concentration. Effect of Saffron on spermatogenesis index and unfertilization in human needed to be more investigation.

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Simultaneous quantification of five major biologically active ingredients of saffron by high-performance liquid chromatography

Cited by 121 publications

References 19 publications

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

Evaluation of antioxidant activities of bioactive compounds and various extracts obtained from saffron (Crocus sativus L.): a review

Quality control of herbal medicines

Effect of Saffron on Histomorphometric Changes of Testicular Tissue in Rat

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