“…With the advent of PCI and stenting, the mechanisms for iatrogenic perforation are being attributed to: aggressive manipulation of rigid wires into subendothelial spaces, when attempting to re-canalise tight lesions [ 3 , 11 , 12 , 14 , 16 , 19 , 22 ]; forceful manipulation of guiding catheters that are either wedged [ 17 ] or in a non-coaxial position relative to the proximal segment of the coronary artery [ 2 – 4 , 6 , 8 , 10 – 15 , 17 , 18 , 20 , 22 , 27 , 28 ]; and prolonged balloon inflations [ 3 , 12 ]. A vigorous manual injections of contrast medium into the subintimal space plays a major role in extending the dissection further, by generating reverse flow proximal to the catheter tip and causing retrograde extension [ 3 , 4 , 8 , 11 , 14 , 15 , 17 – 19 , 21 , 28 ].…”