Simultaneous spectral domain OCT and fundus autofluorescence imaging of the macula and microperimetric correspondence after successful repair of rhegmatogenous retinal detachment

Lai, Wico W.; Leung, Gloria Y. O.; Chan, Catherine W S; Yeung, Ian; Wong, David

doi:10.1136/bjo.2009.163584

Cited by 92 publications

(56 citation statements)

References 26 publications

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“…SD-OCT has allowed us to image the foveal microstructural anatomic abnormalities of the outer retina to the extent that we can predict functional recovery with a greater degree of accuracy. Similar to previous reports concerning retinal reattachment, where the integrity of the ELM was identified as a critical parameter for predicting Eye restoration of photoreceptors, 8,9 our findings suggest that combined disruptions of the ELM and IS-OS junction predict worse visual outcomes for MH repair than isolated IS-OS disruptions. The findings of this article complement those of Wakabayashi et al, 15 who, while studying ELM recovery, IS-OS recovery, and visual outcomes following MH repair, found that early postoperative reconstruction of the foveal ELM helps predict restoration of the foveal photoreceptors and better visual outcomes.…”

Section: Discussionsupporting

confidence: 90%

“…The integrity of the ELM appears to have a critical role in restoration of the photoreceptor microstructures. 8,9 Several clinicopathological studies of MH repair have suggested that anatomical repair of full-thickness MHs requires proliferation of glial cells, believed to be originated from Mü ller cells. [10][11][12][13] Madreperla et al 11 demonstrated the sealing of a break in the ELM by Mü ller cell processes in an eye with a stage III MH.…”

Section: Introductionmentioning

confidence: 99%

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External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

Landa

Gentile

Garcia

et al. 2011

Eye

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Purpose To investigate the relationship between postoperative visual acuity and integrity of the external limiting membrane (ELM) and inner segment-outer segment (IS-OS) junction layers, using spectral domain optical coherence tomography (SD-OCT), in eyes with macular holes (MHs) following surgical repair. Methods Medical charts of MH-operated cases were retrospectively identified and reviewed. The primary outcome measures were best-corrected visual acuity (BCVA) and the status of the ELM and IS-OS lines, using SD-OCT, at 6 weeks and 6 months postoperatively. Results Sixty-two eyes of 62 patients were included. At 6 weeks following surgery, out of 56 (90.3%) eyes with successful MH closure: 0 eyes showed the combination of disrupted ELM and continuous IS-OS layers; 7 eyes (12.5%) demonstrated continuity of both ELM and IS-OS (ELM c /IS-OS c group); 29 eyes (51.8%) had continuous ELM with discontinuous IS-OS layers (ELM c /IS-OS d group); and 20 eyes (35.7%) had discontinuities in both the layers (ELM d /IS-OS d group). The ELM d /IS-OS d group had the lowest visual gain at 6 months (P ¼ 0.03). At 6 months, a restoration of the integrity of IS-OS layer was observed in 51.7% eyes in the ELM c /IS-OS d group and in 5% in the ELM d /IS-OS d group (P ¼ 0.001). Conclusions When both ELM and IS-OS layers showed disruptions 6 weeks postoperatively, a significantly worse BCVA was measured at 6 months, compared with the eyes with only IS-OS disruptions, detected 6 weeks following surgery. The integrity of the ELM layer appears to be a critical factor for the restoration of the photoreceptor layer and for predicting a successful visual outcome following MH repair.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

Landa

Gentile

Garcia

et al. 2011

Eye

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“…10,11 The current report used an ultra-wide-field camera that allows a 2001 view of the retina with a single frame. Peripheral views of the retina are valuable in imaging RRDs because this condition is a peripheral disease (ie, results from a retinal break in the periphery that may progress posteriorly).…”

Section: Discussionmentioning

confidence: 99%

Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment

Witmer

Cho

Favarone

et al. 2012

Eye

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Purpose Rhegmatogenous retinal detachment (RRD) affects the function of the retina before and after surgical repair. We investigated ultra-wide-field autofluorescence (UAF) abnormalities in patients with acute RRD to improve our understanding of the functional changes in the retina before and after surgery. Methods In this retrospective study, we present the UAF imaging findings of 16 patients with acute, non-traumatic RRD. Imaging was obtained with the Optos 200 Tx (Optos) in 14 eyes preoperatively and in 12 eyes postoperatively. Twelve eyes had RRDs that involved the macula (group A), whereas four eyes had macula-sparing RRDs (group B). Results All patients (100%) with bullous retinal detachments demonstrated hypofluorescence over the area of retinal detachment. A hyperfluorescent leading edge (HLE) to the retinal detachment was observed preoperatively in 100% of eyes in group A and 75% of eyes in group B. Preoperative UAF through the fovea of group A eyes was normal (30%), hypofluorescent (50%) or hyperfluorescent (20%). In all patients with a HLE preoperatively, the HLE resolved by the 1-month postoperative visit. A residual line of demarcation remained in 8 of the 12 eyes (67%). In group A eyes, postoperative granular autofluorescent changes were present in four of the nine (44%) eyes, and were associated with worse preoperative (P ¼ 0.04) and postoperative (P ¼ 0.09) visual acuity. Conclusion UAF imaging reveals abnormalities in RRDs that allow excellent demarcation of the extent of the retinal detachment and assist in preoperative characterization of the detachment and postoperative counselling.

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“…Spectral-domain optical coherence tomography provided direct visualization of in vivo retinal morphology, allowing high-resolution observation of individual layers of the macula, thereby providing greater information for structural postoperative macular changes. Recent OCT studies have reported disruptions of photoreceptor microstructures and integrity of the outer retinal bands at the fovea in cases of macula-off RRD 5,[17][18][19]32,33 and other retinal diseases (e.g., macular hole 20,34 and central serous chorioretinopathy 35 ). In the present study, SD-OCT facilitated precise measurement of retinal layer thickness and evaluation of outer retinal band integrity.…”

Section: Discussionmentioning

confidence: 99%

Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

Kobayashi

Iwase

Yamamoto

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to evaluate foveal regeneration and the association between retinal restoration and visual acuity following reattachment surgery for rhegmatogenous retinal detachment (RRD).METHODS. Twenty-nine eyes of 29 patients with successfully reattached macula-off RRD were retrospectively analyzed. We used spectral-domain optical coherence tomography to image macular regions and measure retinal thickness and Snellen chart visual acuity (VA) to evaluate best-corrected VA (BCVA) at 1, 2, 3, 6, 9, and 12 months after vitrectomy. Best-corrected visual acuity data were converted to the logarithm of the minimum angle of resolution scale. Opposite eyes were used as controls.RESULTS. The thicknesses of the external limiting membrane (ELM)-ellipsoid zone (EZ) and EZretinal pigment epithelium (RPE) were significantly thinner in involved eyes than in corresponding unaffected eyes at 1 month after surgery (P < 0.001 for both), and the thickness increased over time (P < 0.001 for both). Best-corrected visual acuity significantly improved over time (P < 0.001), and the improvement correlated with EZ-RPE thickness (r ¼ À0.45, P ¼ 0.021). Multiple regression analysis demonstrated the presence of a foveal bulge as the independent predictor of final BCVA (P < 0.001). Eyes with a foveal bulge had significantly better BCVA and greater EZ-RPE thickness than those without throughout the follow-up period. Significant restoration of the integrity of EZ and cone interdigitation zone (CIZ) was observed over time (P < 0.001 for both) in eyes with a foveal bulge.CONCLUSIONS. The thickness of EZ-RPE and cone density increased during foveal regeneration, as demonstrated by the continuous improvements in CIZ integrity over time, leading to the formation of foveal bulge and good vision following successful reattachment of macula-off RRD.

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Simultaneous spectral domain OCT and fundus autofluorescence imaging of the macula and microperimetric correspondence after successful repair of rhegmatogenous retinal detachment

Abstract: FAF changes may lag behind ultrastructural changes in the OCT, some of which may reverse with the passage of time. The present study demonstrates the ultrastructural changes assessed with simultaneous FAF and sdOCT and their relation with visual outcome.

Cited by 92 publications

References 26 publications

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

External limiting membrane and visual outcome in macular hole repair: spectral domain OCT analysis

Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment

Association Between Photoreceptor Regeneration and Visual Acuity Following Surgery for Rhegmatogenous Retinal Detachment

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