Simultaneous Spectrophotometric Determination of Cobalt and Nickel by Partial Least Square Regression in Micellar Media

A new ultraviolet spectrophotometric method has been developed for the direct qualitative determination of captopril in pharmaceutical preparation and biological fluids such as human plasma and urine samples. The method was accomplished based on parallel factor analysis (PARAFAC) and partial least squares (PLS). The study was carried out in the pH range from 2.0 to 12.8 and with a concentration from 0.70 to 61.50 microg ml(-1) of captopril. Multivariate calibration models PLS at various pH and PARAFAC were elaborated from ultraviolet spectra deconvolution and captopril determination. The best models for this system were obtained with PARAFAC and PLS at pH = 2.04 (PLS-PH2). The applications of the method for the determination of real samples were evaluated by analysis of captopril in pharmaceutical preparations and biological (human plasma and urine) fluids with satisfactory results. The accuracy of the method, evaluated through the root mean square error of prediction (RMSEP), was 0.58 for captopril with PARAFAC and 0.67 for captopril with PLS-PH2 model. Acidity constant of captopril at 25 degrees C and ionic strength of 0.1 M have also been determined spectrophotometrically. The obtained pKa values of captopril are 3.90 +/- 0.05 and 10.03 +/- 0.08 for pKa. and pKa2, respectively.

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“…25 Application of PLS in spectrophotometry has been reported by several papers. [27][28][29][30][31][32] .…”

Section: Introductionmentioning

confidence: 99%

Parafac and PLS Applied to Determination of Captopril in Pharmaceutical Preparation and Biological Fluids by Ultraviolet Spectrophotometry

Ниази¹,

Ghasemi²

2007

Annali di Chimica

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“…Likewise, Adewuyi et al [9] have proposed an analytical method based on the preconcentration of nickel on nanofibers of poly-(acrylic acid) functionalized with pyridilazo-2naphthol and followed by fluorescence detection. Concerning chemometrics, overlapping peaks of UV-visible spectra of interferent metal complexes for nickel determination has been solved by derivative spectroscopy [6], Partial Least Squares calibration [10,11] or light-absorption ratio variation approach (LARVA) [12]. However, solid-phase extraction procedures or exploitation of UV-visible spectra are difficult to apply to microplate analyses.…”

Section: Introductionmentioning

confidence: 99%

Determination of dissolved nickel in natural waters using a rapid microplate fluorescence assay method

Robert‐Peillard

Mouchtari²,

Bonne³

et al. 2022

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…Cobalt is an element of high industrial importance in alloying, coating and dyeing. It is used as a catalyst because of its important properties; it is a transitional element and also has biological usages as this element can be an active center of auxiliary enzymes, for example vitamin B (cyanocobalamin), which is used as radiation therapy for cancer patients [6,7].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Cobalt(II) and Lead(II) Using (1,5-Dimethyl-2-Phenyl-4-((2,3,4-Trihydroxy Phenyl) Diazenyl)-1H-Pyrazol-3(2H)-One) as Organic Reagent: Using It as Antimicrobial and Antioxidants

Essa¹,

Hoidy²

2020

Nano BioMed ENG

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The azo organic reagent (1,5-dimethyl-2-phenyl-4-((2,3,4-trihydroxy phenyl) diazenyl)-1H-pyrazol-3(2H)-one) (DPTPD) was prepared and used for the spectrophotometric determination of cobalt(II) and Lead(II), by the selective and surfactant-sensitized method based on the ternary complexes formation of Co(II) and Pb(II). The reagent had absorption maximum at 381 nm, and reacted with Co 2+ to form a purple reddish complex with λ max = 430 nm at pH = 7.5, while it formed a red complex with Pb 2+ of λ max = 417 nm at pH= 6. Beer's law for the determination over the range of 1-25 ppm and 1-33 ppm for Co(II) and Pb(II), respectively. The molar absorptivity (Є) and Sandell's sensitivity values of Co(II) and Pb(II) complexes were found to be 1.02×10 4 , 3.3×10 4 mol-1 cm-1 , and 0.0725, 0.0269 μg cm-2 at 430, 417 nm, respectively. The stability constant was found to be 1.1×10 8 L mol-1 and 2.3×10 8 L mol-1 for Co(II) and Pb(II), respectively. Detection limit relative standard deviation, relative error and recovery were predestined for 15 ppm standard solution of Co(II) and Pb(II) complexes, respectively. The important interferences with most ions like Cr +3 , Mn 2+ , Fe 3+ , Zn 2+ , Hg 2+ , Mo +2 , Pt 2+ and Cd +2 were studied using the appropriate masking agents. The method was applied for the determination of Co(II) in filling sample; the result obtained was incompatible with that by the flame atomic absorption spectrometry method. The organic reagent (DPTPD) was diagnosed as an antibacterial and an antioxidant.

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Simultaneous Spectrophotometric Determination of Cobalt and Nickel by Partial Least Square Regression in Micellar Media

Cited by 8 publications

References 45 publications

Parafac and PLS Applied to Determination of Captopril in Pharmaceutical Preparation and Biological Fluids by Ultraviolet Spectrophotometry

Parafac and PLS Applied to Determination of Captopril in Pharmaceutical Preparation and Biological Fluids by Ultraviolet Spectrophotometry

Determination of dissolved nickel in natural waters using a rapid microplate fluorescence assay method

Spectrophotometric Determination of Cobalt(II) and Lead(II) Using (1,5-Dimethyl-2-Phenyl-4-((2,3,4-Trihydroxy Phenyl) Diazenyl)-1H-Pyrazol-3(2H)-One) as Organic Reagent: Using It as Antimicrobial and Antioxidants

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