Simultaneous unpinning of multiple vortices in two-dimensional excitable media

Wörden, Henrik tom; Parlitz, Ulrich

doi:10.1103/physreve.99.042216

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…Several numerical and experimental studies have investigated mechanisms related to arrhythmia control and defibrillation ( Trayanova et al, 2011 ; Rantner et al, 2013 ), including the formation of virtual electrodes ( Efimov and Ripplinger, 2006 ), interaction of electric fields with cardiac tissue and curved boundaries ( Pumir and Krinsky, 1999 ; Bittihn et al, 2012 ), the unpinning of rotational waves ( Pumir et al, 2007 ; Bittihn et al, 2008 ; Bittihn et al, 2010 ; Shajahan et al, 2016 ; Boccia et al, 2017a ; Boccia et al, 2017b ; tom Wörden et al, 2019 ), the effect of pacing frequency ( Hornung et al, 2017 ), the electric field geometry ( Otani et al, 2019 ) and electrode placing ( Trayanova and Chang, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm

Aron

Lilienkamp

Parlitz

2023

Front. Netw. Physiol.

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Sequences of low-energy electrical pulses can effectively terminate ventricular fibrillation (VF) and avoid the side effects of conventional high-energy electrical defibrillation shocks, including tissue damage, traumatic pain, and worsening of prognosis. However, the systematic optimisation of sequences of low-energy pulses remains a major challenge. Using 2D simulations of homogeneous cardiac tissue and a genetic algorithm, we demonstrate the optimisation of sequences with non-uniform pulse energies and time intervals between consecutive pulses for efficient VF termination. We further identify model-dependent reductions of total pacing energy ranging from ∼4% to ∼80% compared to reference adaptive-deceleration pacing (ADP) protocols of equal success rate (100%).

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Section: Introductionmentioning

confidence: 99%

Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm

Aron

Lilienkamp

Parlitz

2023

Front. Netw. Physiol.

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“…Recently, many groups have started using periodic field pulses to increase the chances of unpinning and these are found to be very effective in LEAP [15,16]. Studies so far have focused on unpinning a rotating wave by secondary excitations emanating from the pinning centre itself (except a very recent paper by Tom Wörden et al, which studied control of multiple pinned spirals in an excitable media [17]). However, these studies show that unpinning window is quite narrow compared to the experimental studies in intact heart [16,18].…”

Section: Introductionmentioning

confidence: 99%

Spiral wave unpinning facilitated by wave emitting sites in cardiac monolayers

et al. 2019

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Rotating spiral waves of electrical activity in the heart can anchor to unexcitable tissue (an obstacle) and become stable pinned waves. A pinned rotating wave can be unpinned either by a local electrical stimulus applied close to the spiral core, or by an electric field pulse that excites the core of a pinned wave independently of its localization. The wave will be unpinned only when the pulse is delivered inside a narrow time interval called the unpinning window (UW) of the spiral. In experiments with cardiac monolayers, we found that other obstacles situated near the pinning centre of the spiral can facilitate unpinning. In numerical simulations, we found increasing or decreasing of the UW depending on the location, orientation and distance between the pinning centre and an obstacle. Our study indicates that multiple obstacles could contribute to unpinning in experiments with intact hearts.

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Termination of a pinned spiral wave by the wave train with a free defect

Gao

Yan

et al. 2021

Nonlinear Dyn

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Simultaneous unpinning of multiple vortices in two-dimensional excitable media

Cited by 6 publications

References 19 publications

Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm

Optimising low-energy defibrillation in 2D cardiac tissue with a genetic algorithm

Spiral wave unpinning facilitated by wave emitting sites in cardiac monolayers

Termination of a pinned spiral wave by the wave train with a free defect

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