Simultaneously detected primary malignant tumors of ovary and endometrium with unusual histology

Papathanasiou, K.; Tolikas, A; Dovas, Dimitrios; Kostopoulou, E.; Fragkedakis, N.; Tzafettas, J

doi:10.1111/j.1525-1438.2005.00188.x

Cited by 6 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, according to the reports, the prognosis in most cases of double primary malignant tumor is surprisingly good. It is reported that the prognosis of the "highly malignant" tumor does not worsen as a result of a second malignant cancer [8] and furthermore the prognosis of double primary carcinoma of uterine corpus and ovary is rather good [9,10]. The precise mechanism of good prognosis of double primary cancer has not been revealed yet.…”

Section: Discussionmentioning

confidence: 99%

A case of double primary cancers of uterine endometrium and bladder with unusual histology

Kim

Park

2011

Korean J Obstet Gynecol

View full text Add to dashboard Cite

A case of a moderate differentiated endometrial carcinoma of the uterus with a synchronous poorly differentiated bladder cancer is reported. A review of the literature revealed that simultaneous presentation of primary endometrial and bladder neoplasm is rare and usually related to low-stage bladder lesions in contrast to our case with undifferentiated and the deep myometrial invasion of bladder lesion. A 79-year-old woman with endometrial cancer stage IB was performed of total abdominal hysterectomy with bilateral salpingo-oophorectomy, pelvic and para-aortic lymph nodes dissection and adjuvant concurrent cisplatin-radiation therapy. After treatment, she complained intermittent gross hematuria. She was performed the bladder mucosal biopsy and fi nally diagnoses with poorly differentiated carcinoma of bladder. She received transurethral resection of bladder tumor alone without total cystectomy or any other adjuvant treatment due to her refusal. Her condition is tolerable except intermittent hematuria and anemia.

show abstract

Section: Discussionmentioning

confidence: 99%

A case of double primary cancers of uterine endometrium and bladder with unusual histology

Kim

Park

2011

Korean J Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…The bulk of studies identified in this systematic review were retrospective cohort studies with <50 patients with SEOC (6-10, 12, 22, 24, 25, 28, 31, 34, 37, 38, 42, 44, 49, 51, 52, 55, 56, 58, 59, 61, 62, 65, 67-71), cases series of individual patients (13,23,35,36,43,45,66,73), and case reports (26,27,32,33,41,46,50,53,54,57,60,63,64,72,74,75). As expected, the heterogeneity among these studies with low numbers of patients was high.…”

Section: Immunohistochemical Stains Of An Endometrial Cancer Specimenmentioning

confidence: 99%

Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature

Doğan

Schultheis

Rezniczek

et al. 2017

View full text Add to dashboard Cite

Abstract. Background: Young women with endometrial cancer (EC) have an increased risk of synchronous ovarian cancer. The prognosis of women with synchronous endometrial and ovarian cancer (SEOC) is good. A high proportion of affected women have hereditary non-polyposis colon cancer syndrome (HNPCCEndometrial cancer (EC) is the most common female pelvic malignancy with a life-time risk of 4% (1). It is usually diagnosed at an early stage and has a good prognosis accounting for only 2% of cancer-related deaths (1, 2). The most common age at the time of diagnosis is between 65 and 75 years with a mean age of 69 years (3). However, young women may also be affected by EC. Specifically, around 10% of women diagnosed with EC are <50 years of age with a range of 7 to 20% reported in the literature (1-4). This subset of women with EC is characterized by an elevated risk of synchronous ovarian cancer and an increased prevalence of hereditary non-polyposis colon cancer syndrome (HNPCC). This has important consequences for the management, prognosis, and genetic counselling of young women with EC.In the general population of women with EC, synchronous ovarian cancer is a rare finding. In a Surveillance, Epidemiology, and End Results Program (SEER) database analysis of 56986 women with ovarian cancer, for example, Williams et al. identified 1709 (3%) cases of synchronous endometrial and ovarian cancer (SEOC) (5). Young women with EC, however, have a significantly higher risk of SEOC with a range of 11 to 29% reported in the literature (4, 6-11). The typical histology of SEOC is endometrioid adenocarcinoma in both the endometrium and the ovary, which is found in >70% of cases (12). Based on this high rate of histological congruence among SEOC cases, a monoclonal origin has been suggested (13). Specifically, 969

show abstract

“…However, when both tumors share the same histological features, it may be difficult to distinguish between metastatic and independent malignancies. 14,15 For accurate differentiation of these 2 distinct cancers, several clinicopathologic criteria have been proposed. In 1985, Ulbright and Roth 9 delineated a set of pathological criteria to help distinguish metastatic disease from synchronous primary tumors.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Primary Carcinoma in 5 Different Organs of a Female Genital Tract

Atasever

Yılmaz²,

Dilek

et al. 2009

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

The occurrence of double simultaneous primary cancers of the female reproductive tract is a common event. However, the occurrence of synchronous primary quadruple gynecologic malignancies is extremely rare. In this report, the clinical and pathological findings of a 35-year-old female patient with synchronous primary gynecologic cancers regarding papillary serous carcinoma of the left ovary, microinvasive carcinoma in situ of the left and right uterine tubes, endometrial intraepithelial carcinoma of the endometrium, and endocervical carcinoma in situ of the uterine cervix were presented. To our knowledge, the patient presented is the first case in aspect of accompanying ovarian papillary serous carcinoma to bilateral tubal microinvasive carcinoma in situ, endometrial intraepithelial carcinoma, and endocervical carcinoma in situ of the uterine cervix.

show abstract

Simultaneously detected primary malignant tumors of ovary and endometrium with unusual histology

Cited by 6 publications

References 12 publications

A case of double primary cancers of uterine endometrium and bladder with unusual histology

A case of double primary cancers of uterine endometrium and bladder with unusual histology

Synchronous Endometrial and Ovarian Cancer in Young Women: Case Report and Review of the Literature

Synchronous Primary Carcinoma in 5 Different Organs of a Female Genital Tract

Contact Info

Product

Resources

About