Simvastatin for Migraine Prevention

Medeiros, Fabíola Lys de; Medeiros, Paloma Lys de; Valênça, Marcelo Moraes; Dodick, David W.

doi:10.1111/j.1526-4610.2007.00824.x

Cited by 23 publications

(9 citation statements)

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“…Statin has been reported to be efficacious for migraine prophylaxis in a case report using atorvastatin 20 mg [ 131 ] and a small open-label prospective study using simvastatin 20 mg [ 132 ]. A recent randomized controlled trial showed effectiveness of simvastatin 20 mg combined with vitamin D for preventive treatment of migraine [ 133 ].…”

Section: Clinical Pearls For Managing Migraine In Patients With Ischementioning

confidence: 99%

The Migraine–Stroke Connection

Lee

Chung

2016

J Stroke

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Migraine and stroke are common neurovascular disorders which share underlying physiological processes. Increased risks of ischemic stroke, hemorrhagic stroke, and subclinical ischemic lesions have been consistently found in migraineurs. Three possible associations are suggested. One is that underlying pathophysiology of migraine can lead to ischemic stroke. Second, common comorbidities between migraine and stroke can be present. Lastly, some syndromes can manifest with both migraine-like headache and cerebrovascular disease. Future studies should be targeted on bidirectional influence of migraine on different stroke mechanisms and optimal prevention of stroke in migraine patients.

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Section: Clinical Pearls For Managing Migraine In Patients With Ischementioning

confidence: 99%

The Migraine–Stroke Connection

Lee

Chung

2016

J Stroke

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“…Both groups reduced the number of days with headache by > 50%. 139 In another study, use of simvastatin 20 mg þ vitamin D 1,000 units twice daily was compared with a placebo group for treatment of EM over a 24-week followup period. In the simvastatin group, 25% of the patients reduced the number of migraine days by > 50% with 12 weeks of treatment and 29% achieved this after 24 weeks of treatment.…”

Section: Studiesmentioning

confidence: 99%

Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II

et al. 2022

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Background Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder. Objective The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience. Methods Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy. Results From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease. Conclusions Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options.

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“…Nitroglycerine, when administered to migraineurs, is able to trigger a headache with characteristics similar to those of migraine attacks ( 4 ), strongly indicating that the production of NO is involved in a migraine crisis. Previously, we measured the serum NO levels in 357 women during a migraine attack ( 5 , 6 ). The levels were significantly higher during the migraine attack than at times when they were without pain ( 5 , 6 ).…”

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confidence: 99%

“…Previously, we measured the serum NO levels in 357 women during a migraine attack ( 5 , 6 ). The levels were significantly higher during the migraine attack than at times when they were without pain ( 5 , 6 ). Interestingly, preventive treatment with either propranolol or amitriptyline induced a significant decline in the serum levels of NO after 2, 4, and 6 months ( 5 , 6 ).…”

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confidence: 99%

“…Interestingly, preventive treatment with either propranolol or amitriptyline induced a significant decline in the serum levels of NO after 2, 4, and 6 months ( 5 , 6 ). In addition, simvastatin, a drug known to inhibit inductive NO synthase and stimulate endothelial NO synthase, also decreased the NO concentration in the serum, an effect associated with a significant decline in the frequency of migraine attacks in dyslipidemic women ( 5 , 6 ).…”

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confidence: 99%

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