Síndrome de superposición: hepatitis autoinmune y colangitis biliar primaria. Resultados a largo plazo de una cohorte retrospectiva en un hospital universitario

Casas, Omar Yesid Martínez; Ramírez, Gabriel Sebastián Díaz; Zuluaga, Juan Ignacio Marín; Santos, Óscar; Maya, Octavio Muñoz; Gómez, Jorge Hernando Donado; Gutiérrez, Juan Carlos Restrepo

doi:10.1016/j.gastrohep.2018.05.019

Cited by 10 publications

(1 citation statement)

References 16 publications

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“…Although PBC patients generally have a normal life expectancy, they sometimes show rapid disease exacerbation due to concomitant autoimmune hepatitis ( 7 , 21 ) or simultaneous HCV infection ( 22 ) as a trigger of PBC deterioration. One rare instance of PBC with acute HEV infection has been reported to date ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

An Autopsy Case of Primary Biliary Cholangitis with Histological Submassive Hepatic Necrosis Caused by Acute Hepatitis E Virus Infection

et al. 2021

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A 59-year-old woman who had been diagnosed with cirrhotic primary biliary cholangitis (PBC) 5 years earlier was admitted for severe jaundice (total bilirubin: 30.1 mg/dL). We suspected that her cirrhotic PBC had deteriorated acutely for some reason. Her general condition deteriorated quickly, and she passed away on day 18 of admission. Hepatitis E virus (HEV)-IgA antibodies were positive, and Genotype 3b HEV involvement was confirmed from a blood sample taken on admission. Histopathological findings revealed cirrhosis and submassive loss and necrosis of hepatocytes. Clinicians should consider the possibility of acute HEV infection as a trigger for acute PBC exacerbation.

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