Síndrome hemofagocítico asociado con dengue hemorrágico

Rueda, Ernesto; Méndez, Ángela; González, Gerardo

doi:10.7705/biomedica.v22i2.1155

Cited by 18 publications

(10 citation statements)

References 24 publications

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“…False-positive dengue NS1 tests have not been reported in hematological malignancies. Although there are case reports of dengue fever causing hemophagocytosis [31,32].…”

Section: Discussionmentioning

confidence: 99%

Case Report: False-Positive Dengue Non-Structural Protein 1 Antigen in a Patient with COVID-19 Infection

et al. 2020

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Early diagnosis of dengue fever and COVID-19 is made very easy due to technological advancements. The non-structural protein 1 antigen test strips are widely used in various regions; however, false-positive events have begun to be reported in the dengue-endemic areas with the COVID-19 pandemic, even though statistically non-structural protein 1 antigens are very specific to dengue infection. We reported a case of the false-positive non-structural protein 1 test in a patient with COVID-19 infection.

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“…False-positive dengue NS1 tests have not been reported in hematological malignancies. Although there are case reports of dengue fever causing hemophagocytosis [31,32].…”

Section: Discussionmentioning

confidence: 99%

Case Report: False-Positive Dengue Non-Structural Protein 1 Antigen in a Patient with COVID-19 Infection

et al. 2020

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“…Although dengue is usually a self-limited disease, many complications have been described; 2 , 6 , 7 among them the HLH has been increasingly reported. 4 - 19 …”

Section: Discussionmentioning

confidence: 99%

Dengue fever as a cause of hemophagocytic lymphohistiocytosis

Hein¹,

Bergara²,

Moura³

et al. 2015

ACR

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Dengue is endemic in more than 100 countries in Southeast Asia, the Americas, the western Pacific, Africa and the eastern Mediterranean regions. The virus is transmitted by Aedes mosquitoes. Dengue disease is the most prevalent arthropod-borne viral disease in humans and is a global and national public health concern in several countries. A seasonal pattern of dengue disease is consistently observed. The highest incidences usually correspond to the period of highest rainfall and humidity, providing suitable conditions for Aedes aegypti breeding and survival. In Brazil for instance it is from January to June. Dengue may cause marked changes in bone marrow that result in hypocellularity and, consequently, thrombocytopenia and leucopenia, along with an increase in hematocrit, which is secondary to capillary leakage. However, those abnormalities are usually self-limited, and do not warrant further investigations, such as a marrow biopsy or a myelogram. The occurrence of persistent reactive hemophagocytosis is uncommon and usually leads to serious adverse outcomes. The authors report the case of an 8-year old girl complaining of high-grade fever, malaise, headache, abdominal pain and a cutaneous rash. Laboratory examination revealed atypical lymphocytosis on peripheral blood count, hyperbilirrunemia, abnormal liver enzymes and clotting tests. Serology was positive for dengue. Because of the persistence of fever and laboratory examinations were consistent with hemophagocytic lymphohistiocytosis (HLH) a bone marrow aspiration was performed, which confirmed the presence of hemophagocytosis. Hence we report a rare presentation of dengue accompanied by self-limited HLH that hopefully evolve to favorable outcome.

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“…Esta entidad no requiere ningún tratamiento específico diferente a las medidas de soporte. Se recomienda que en niños con diagnóstico de dengue hemorrágico cuyo curso clínico sea atípico, con fiebre prolongada y citopenias persistentes, se debe practicar aspirado de médula ósea para descartar una enfermedad linfoproliferativa y por la posibilidad de que la causa de la complicación corresponda a un síndrome hemofagocítico secundario (42).…”

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Manifestaciones clínicas inusuales del dengue hemorrágico en niños.

Méndez¹,

González²

2006

biomedica

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Introducción. Recientemente han venido aumentando los reportes de dengue hemorrágico con manifestaciones inusuales, principalmente neurológicas y hepáticas, que aumentan la morbimortalidad. Objetivo. Describir las manifestaciones inusuales del dengue hemorrágico en niños. Materiales y métodos. En el Departamento de Pediatría del Hospital Universitario de Santander en Bucaramanga, Colombia, de 913 pacientes con diagnóstico de dengue hemorrágico entre 1992 y 2004, se seleccionaron aquéllos que presentaron manifestaciones inusuales. Se clasificaron de acuerdo con los criterios de definición de caso, se agruparon según los órganos o sistemas principalmente comprometidos y se describieron los principales hallazgos clínicos, de laboratorio y relativos a la evolución. Resultados. Se encontraron 168 pacientes que presentaron manifestaciones inusuales, con predominio del sexo masculino, edad escolar y grados III y IV de dengue hemorrágico. Las manifestaciones más frecuentes fueron hepáticas, 53 (27%), y neurológicas, 49 (25%), además de renales, 14 (7%); cardíacas, 15 (8%); pulmonares, 18 (9%); colecistitis alitiásica, 18 (9%); síndrome hemofagocítico, 5 (2,5%); pancreatitis, 2 (1%), y 21 casos de abdomen agudo (11%). Fallecieron 10 pacientes. Conclusión. Se analizan los resultados y se comparan con otros de países endemoepidémicos de dengue; se discute el significado e importancia de las manifestaciones clínicas inusuales, su difícil diagnóstico, casi siempre en forma retrospectiva, y se destaca la frecuencia de las manifestaciones hepáticas y neurológicas que pueden aumentar la morbimortalidad, ante las cuales deben estar alertas los médicos que trabajan en zonas endémicas para reconocerlas.Palabras clave: dengue/complicaciones, fiebre por dengue hemorrágico/diagnóstico, hepatitis/ etiología, encefalitis/diagnóstico, niño. Abnormal clinical manifestations of dengue hemorrhagic fever in childrenIntroduction. Recently, dengue hemorrhagic fever with unusual neurological and hepatic manifestations has been reported in children, with a concomitant increase in morbidity and mortality. Objective. To describe unusual clinical manifestations of dengue hemorrhagic fever in children. Materials and methods. These manifestations were systematically scrutinized in dengue cases occurring between 1992-2004 in the Pediatrics Department of the University Hospital of Santander, Bucaramanga, Colombia. Case reports were examined of 913 patients with clinical symptoms of dengue hemorrhagic fever. They were classified according to standard criteria for dengue hemorrhagic fever and grouped according to the main organs or systems that were affected. Clinical presentation, laboratory results and medical evolution were summarized. Results. Of the 913 cases, 168 showed abnormal clinical manifestations; these were predominant in male school age children and associated mainly with grades III and IV of dengue hemorrhagic fever. The most frequent manifestations were as follows: hepatitis-53 cases (27%), neurological alterations-49 (25%), renal impair...

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Síndrome hemofagocítico asociado con dengue hemorrágico

Cited by 18 publications

References 24 publications

Case Report: False-Positive Dengue Non-Structural Protein 1 Antigen in a Patient with COVID-19 Infection

Case Report: False-Positive Dengue Non-Structural Protein 1 Antigen in a Patient with COVID-19 Infection

Dengue fever as a cause of hemophagocytic lymphohistiocytosis

Manifestaciones clínicas inusuales del dengue hemorrágico en niños.

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