Single agent vinorelbine in the treatment of unresectable lung metastases from colorectal cancer

Gebbia,; Maiello, Evaristo; Testa, Antonio; Cannata, G; Colucci, Giuseppe; Gebbia, Nicola

doi:10.3892/or.3.3.563

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Vinorelbine has been rarely used for the treatment of colon cancer. Only three studies have been reported (Gebbia et al, 1996;Iaffaioli et al, 1995;Linn et al, 1994). The tumor of one patient who got complete and lasting remission after vinblastine treatment could be retrieved (Linn et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione

Gambino

Raaijmakers

et al. 2016

Cell

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BRAF(V600E) mutant colon cancers (CCs) have a characteristic gene expression signature that is also found in some tumors lacking this mutation. Collectively, they are referred to as "BRAF-like" tumors and represent some 20% of CCs. We used a shRNA-based genetic screen focused on genes upregulated in BRAF(V600E) CCs to identify vulnerabilities of this tumor subtype that might be exploited therapeutically. Here, we identify RANBP2 (also known as NUP358) as essential for survival of BRAF-like, but not for non-BRAF-like, CC cells. Suppression of RANBP2 results in mitotic defects only in BRAF-like CC cells, leading to cell death. Mechanistically, RANBP2 silencing reduces microtubule outgrowth from the kinetochores, thereby inducing spindle perturbations, providing an explanation for the observed mitotic defects. We find that BRAF-like CCs display far greater sensitivity to the microtubule poison vinorelbine both in vitro and in vivo, suggesting that vinorelbine is a potential tailored treatment for BRAF-like CCs.

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