Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae

Zheng, Yan; Liu, Xinjie; Yang, Feng; Li, Rongzhen; Xiong, Ying; Fu, Caixia; Li, Guanrong; Liu, Shuai; Chen, Kewei

doi:10.1016/j.scitotenv.2020.137062

Cited by 72 publications

(34 citation statements)

References 71 publications

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“…2014c; Qiu et al . 2020) and time‐related (Liu et al . 2014b) effects (Table 5) as mechanisms to reduce ROS production, indicating oxidative stress (Yonar et al .…”

Section: Oxidative Stress and Other Toxicitiesmentioning

confidence: 99%

“…2016); sometimes, the latter method rendered stronger toxicity than single exposure (Qiu et al . 2020).…”

Section: Oxidative Stress and Other Toxicitiesmentioning

confidence: 99%

“…2019), and single and combined antibiotics disrupted several nutrients metabolic pathways (Qiu et al . 2020), highlighting physiological stress in treated fish. Antibiotics may also impair nutrients metabolism through reduced digestive enzymes activities and nutrients digestibility, microbiota dysbiosis, liver histopathology and hepatotoxicity as indicated previously in this review.…”

Section: Nutrients Metabolismmentioning

confidence: 99%

“…The induced detoxification toxicity is occasionally similar for mixed and single antibiotics (Qiu et al . 2020).…”

Section: Detoxification and Biotransformation Responsesmentioning

confidence: 99%

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A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Limbu

Chen

Zhang

et al. 2020

Reviews in Aquaculture

141

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The rearing of fish in intensive systems reduces their immunity leading to eruption of diseases, consequently prompting the use of antibiotics. Antibiotics are currently used in cultured fish globally to treat/prevent diseases. On the one hand, antibiotics used in aquaculture help to improve fish health by killing or inhibiting pathogenic bacteria proliferation. However, on the other hand, they cause multiple side effects. To date, information on systemic effects of antibiotics in cultured fish is scattered and their potential human health risk remains elusive. This review critically analyses and discusses the available information in the literature on the positive and negative effects of antibiotics in cultured fish and their potential human health risk via fish consumption. The review found 44 different antibiotics dominated by oxytetracycline were studied in various fish species worldwide. Antibiotics used in global aquaculture either decrease or increase fish growth and survival rates. They induce oxidative stress, which affect antioxidant and detoxification responses and cause host–microbiota dysbiosis. These changes compromise the fish immunity system, which ultimately lead to cellular damage. The toxicities generated inhibit the fish aerobic glycolysis, suppress lipogenesis and fatty acid β‐oxidation while increase energy demand by initiating gluconeogenesis and anaerobic glycolysis. Consumption of fish treated with antibiotics causes human health risk. Future studies are required on agents to restore dysfunctions induced by antibiotics in cultured fish, while attempts to limit their utilisation in aquaculture production are underway. [Correction added on 21 November 2020, after first online publication: The abstract has been amended to clarify the scope of the review.]

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“…2014c; Qiu et al . 2020) and time‐related (Liu et al . 2014b) effects (Table 5) as mechanisms to reduce ROS production, indicating oxidative stress (Yonar et al .…”

Section: Oxidative Stress and Other Toxicitiesmentioning

confidence: 99%

“…2016); sometimes, the latter method rendered stronger toxicity than single exposure (Qiu et al . 2020).…”

Section: Oxidative Stress and Other Toxicitiesmentioning

confidence: 99%

Section: Nutrients Metabolismmentioning

confidence: 99%

“…The induced detoxification toxicity is occasionally similar for mixed and single antibiotics (Qiu et al . 2020).…”

Section: Detoxification and Biotransformation Responsesmentioning

confidence: 99%

See 2 more Smart Citations

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Limbu

Chen

Zhang

et al. 2020

Reviews in Aquaculture

141

View full text Add to dashboard Cite

show abstract

“…For instance, the swimming time was observed to decline; furthermore, the regulation of neurotransmitter levels, synapse, neuron parts and sensory perception was affected [ 80 ]. A longer exposure of 120 h to 100 μg/L cefotaxime determined a decrease in the body lengths of zebra fish larvae, an increase in the activity of reactive oxygen species and different changes in the mRNA of various genes [ 83 ]. Several toxic effects were also observed in the exposure to ceftazidime.…”

Section: Effects Of Individual Antibiotics In Zebrafishmentioning

confidence: 99%

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

et al. 2021

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The overuse of antibiotics combined with the limitation of wastewater facilities has resulted in drug residue accumulation in the natural environment. Thus, in recent years, the presence of antibiotic residues in the environment has raised concerns over the potential harmful effects on ecosystems and human health. The in vivo studies represent an essential step to study the potential impact induced by pharmaceutical exposure. Due to the limitations of traditional vertebrate model systems, zebrafish (Danio rerio) has recently emerged as a promising animal model to study the toxic effects of drugs and their therapeutic efficacy. The present review summarizes the recent advances made on the toxicity of seven representative classes of antibiotics, namely aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides, tetracyclines and polyether antibiotics, in zebrafish, as well as the combined effects of antibiotic mixtures, to date. Despite a significant amount of the literature describing the impact of single antibiotic exposure, little information exists on the effects of antibiotic mixtures using zebrafish as an animal model. Most of the research papers on this topic have focused on antibiotic toxicity in zebrafish across different developmental stages rather than on their efficacy assessment.

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Redox Biology in Adipose Tissue Physiology and Obesity

Qiu

Zhang

et al. 2023

Advanced Biology

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Reactive oxygen species (ROS), a by‐product of mitochondrial oxidative phosphorylation and cellular metabolism, is vital for cellular survival, proliferation, damage, and senescence. In recent years, studies have shown that ROS levels and redox status in adipose tissue are strongly associated with obesity and metabolic diseases. Although it was previously considered that excessive production of ROS and impairment of antioxidant capability leads to oxidative stress and potentially contributes to increased adiposity, it has become increasingly evident that an adequate amount of ROS is vital for adipocyte differentiation and thermogenesis. In this review, by providing a systematic overview of the recent understanding of the key factors of redox systems, endogenous mechanisms for redox homeostasis, advanced techniques for dynamic redox monitoring, as well as exogenous stimuli for redox production in adipose tissues and obesity, the importance of redox biology in metabolic health is emphasized.

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Single and joint toxic effects of four antibiotics on some metabolic pathways of zebrafish (Danio rerio) larvae

Cited by 72 publications

References 71 publications

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

A global analysis on the systemic effects of antibiotics in cultured fish and their potential human health risk: a review

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics

Redox Biology in Adipose Tissue Physiology and Obesity

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